Protein Info for A4249_RS14240 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: HAMP domain-containing sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 490 transmembrane" amino acids 36 to 60 (25 residues), see Phobius details amino acids 185 to 213 (29 residues), see Phobius details PF00672: HAMP" amino acids 208 to 259 (52 residues), 27.3 bits, see alignment 5.8e-10 PF00512: HisKA" amino acids 271 to 333 (63 residues), 30.3 bits, see alignment E=5.3e-11 PF02518: HATPase_c" amino acids 376 to 489 (114 residues), 81.1 bits, see alignment E=1.2e-26

Best Hits

KEGG orthology group: None (inferred from 72% identity to bsb:Bresu_0717)

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HZR1 at UniProt or InterPro

Protein Sequence (490 amino acids)

>A4249_RS14240 HAMP domain-containing sensor histidine kinase (Brevundimonas sp. GW460-12-10-14-LB2)
MSALFDRIAARLNLTPDQASLWRERLTPRAPDGLSARLLLLTVAFTLAVEALILGPNLAA
FHERWLRDRLQAAELASVGVEALPYSAVEDDTAAELMRIGGVQAVALTEQGVRRLLLQAP
NLPRAPELIDLRRQDSWSRLTDPWRTLFGHPDRSLRVQAKPRYRSGDFIEIVTPAQPLKL
ELRAFLLNSLLVSLLVSVTAGALLYGGLALLVLRPLRRVTRSMERFAADPESEAEAPSDR
HDEIGRVERELSRMQEEVRHSLRSRARLVALGEAVAKINHDLRNMLTSAQMASERLATSA
DPQVAKALPRLERALSRAAGLSRNVLEYGKSEEPAPQKTRVVLTKALTLAAEDAGLDPDG
VRLVKQLPPRFAVEADPDQLYRILVNLMRNARQAIEADPTRPPERRGKGAITVSAFGQDG
FCVVRIADDGPGIPPRLAERLFEPFVSSKSSDGSGLGLTISRELAALHGGDLRLVETDGT
GAAFELRLPG