Protein Info for A4249_RS13225 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: M2 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 631 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF01401: Peptidase_M2" amino acids 56 to 628 (573 residues), 706.2 bits, see alignment E=1.8e-216

Best Hits

KEGG orthology group: K01283, peptidyl-dipeptidase A [EC: 3.4.15.1] (inferred from 69% identity to aex:Astex_0409)

Predicted SEED Role

"Peptidyl-dipeptidase A precursor (EC 3.4.15.1)" (EC 3.4.15.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.15.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I1E8 at UniProt or InterPro

Protein Sequence (631 amino acids)

>A4249_RS13225 M2 family metallopeptidase (Brevundimonas sp. GW460-12-10-14-LB2)
MKRQMMTAVAVCALAFAAGCASTSEPAAGAPGVEQTASTTPAPAVSGMRADYPITAEGAT
AFIADAETKWAEVSEYVARIQWARATNITFDTMWLESKANAEATELQVQLANQAAKFNDV
QVDPVVRRKLNLLRLSLVLPAPNRPGAADELAQITTRLDSTYSTGKFDFKGKPITLDEAS
LILADSRDPAETKALYEGWRTISPVMRDDYARMVEIANEGSRELGFADTGALWRSGYDMP
ADDFAAETDRLWAQVKPFYENLHCYVRARLNAKYGDAVQPDHGPIRADLLGNMWSQQWGN
IYDVVAPPSGGASSYDLTELLKAADYDATKMVKTGEGFYVSLGLDPLPQTFWERSQITRP
RDREVVCHASAWDLDNADDIRIKMCTNVNGDDFYTVHHELGHNYYQRAYKNQPMLFRNGA
NDGFHEAIGDFVGLSALTPTYLNQIGLLKTTPGAEEDIPFLLKMALDKIAFLPFGLMVDR
WRWDVFSGETAPAAYNTAWTADMLQYQGLVPPGQRPANAFDPGAKYHVPGNTPYTRYFLA
AIYQFQFQRAACKQAGWTGPLHRCSVYGNKEVGARFNAMLQMGQSQPWQEAMKAFTGDDG
NDASAIADYFAPLNVWLQEQNRGHQCGWSAA