Protein Info for A4249_RS13145 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: dienelactone hydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01738: DLH
  • amino acids 68 to 296 (229 residues), 185.4 bits, E=1.7e-58
• PF00326: Peptidase_S9
  • amino acids 142 to 276 (135 residues), 28.3 bits, E=1.8e-10

Best Hits

KEGG orthology group: K01061, carboxymethylenebutenolidase [EC: 3.1.1.45] (inferred from 70% identity to bsb:Bresu_0208)

Predicted SEED Role

"Dienelactone hydrolase family"

MetaCyc Pathways

• 4-chlorocatechol degradation (2/5 steps found)
• 4,5-dichlorocatechol degradation (3/7 steps found)
• 3,4,6-trichlorocatechol degradation (4/9 steps found)
• 3-chlorocatechol degradation I (ortho) (1/5 steps found)
• 3-chlorocatechol degradation II (ortho) (1/5 steps found)
• 3,5-dichlorocatechol degradation (3/8 steps found)
• 1,4-dichlorobenzene degradation (3/9 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Fluorobenzoate degradation
• gamma-Hexachlorocyclohexane degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.45

Sequence Analysis Tools

See A0A160I1X3 at UniProt or InterPro

Protein Sequence (299 amino acids)

>A4249_RS13145 dienelactone hydrolase family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MTVLIRPEGQTADDLKLSRRTLGALGGLLFSGYAIAALAKEAKPITTDEAGLATETVTYA
APDGFQLPAYVARPAGEGPFPVVVVVSEIFGVHEYIRDICRRLAKQGYAAIAPAFFVRVE
DPAPLSDMQRIMQIVGAAHYEQVMGDLSATLEWASQQSWSKDGKVGITGYCWGGKVVWQA
AARFAAIGAGVAWYGRLAPAADATPVQISSGQPWPVDIADDLKAPVLGLYGGKDQGIPLA
SVERMREALARAGQTGSQIVVYPDAQHGFHADYRASYSEADAKDGWSKLLATFDKALKN