Protein Info for A4249_RS12875 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: trypsin-like peptidase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF13365: Trypsin_2" amino acids 80 to 218 (139 residues), 111.4 bits, see alignment E=2e-35 PF00089: Trypsin" amino acids 82 to 231 (150 residues), 49.4 bits, see alignment E=1.6e-16 PF00595: PDZ" amino acids 275 to 335 (61 residues), 33.1 bits, see alignment E=1.8e-11 amino acids 369 to 426 (58 residues), 27.5 bits, see alignment 9.9e-10 PF13180: PDZ_2" amino acids 283 to 349 (67 residues), 49.1 bits, see alignment E=1.7e-16 amino acids 369 to 443 (75 residues), 37.8 bits, see alignment E=5.7e-13 PF17820: PDZ_6" amino acids 285 to 318 (34 residues), 31.8 bits, see alignment 3e-11 amino acids 381 to 426 (46 residues), 34.4 bits, see alignment 4.6e-12

Best Hits

KEGG orthology group: None (inferred from 67% identity to bsb:Bresu_0533)

Predicted SEED Role

"HtrA protease/chaperone protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I1C7 at UniProt or InterPro

Protein Sequence (443 amino acids)

>A4249_RS12875 trypsin-like peptidase domain-containing protein (Brevundimonas sp. GW460-12-10-14-LB2)
MPIRLSPASSMAVALALMASATPVLAQSGAAGLPYDARRGVFSFSSGLEGSLPAVVQVTT
LGQSRGPSSDAADPKPYASGSGVIVDAAEGLVITNNHVVEGGRKFTVDLTDGRLFDAVLV
GADKATDIAVLRITPDGRPLNLKQVQTVDSDTLRTGDLAFAVGYPLGLDQTLTMGVISGL
NRSGLGDAVEDYIQTDAAVNSGNSGGPLLDSRGRLIGINTSILSGGLGGGNDGIAFAVPT
RIMLYVADQLKKNGEVKRGATGAIFGSLNAERARELHLGIVRGAVVADVAPGSPAERAGL
RHNDVITRIQGRPVANAGSVNATIGIAAPGSDLSVSYLRAGREATTSLAVETPADQPVIV
GAQSVLAYGATLRDQDGGAQVTAVAAGSPAAQAELTAGDVITAIAGAPVADARAAAIALQ
GASGSVEATVLRNGEALNLTLSL