Protein Info for A4249_RS12525 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: M3 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 728 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details PF01432: Peptidase_M3" amino acids 280 to 722 (443 residues), 355.3 bits, see alignment E=4e-110

Best Hits

Swiss-Prot: 39% identical to DCP_ECOLI: Dipeptidyl carboxypeptidase (dcp) from Escherichia coli (strain K12)

KEGG orthology group: K01284, peptidyl-dipeptidase Dcp [EC: 3.4.15.5] (inferred from 83% identity to bsb:Bresu_0666)

MetaCyc: 39% identical to peptidyl-dipeptidase Dcp (Escherichia coli K-12 substr. MG1655)
Peptidyl-dipeptidase Dcp. [EC: 3.4.15.5]

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I0L6 at UniProt or InterPro

Protein Sequence (728 amino acids)

>A4249_RS12525 M3 family metallopeptidase (Brevundimonas sp. GW460-12-10-14-LB2)
MHRRQLLIAGGSLMALSACASTGATSGGSAAAPSAASVAEEARIARAVLPRQTPRAELLQ
AWTGKYDGVPPFDKVTPAKLREAMLEGIELQRADIAAIANNPEAPTFANTMAALELAGEP
LDRASNVYGVMTSNIGGEAYDAVDTELSPLLSAAADEITFNEKLFQRVKAVADTADAAGL
SAQQKRLAERRRDAFIRSGANLDAAGKAELGRINTALSNAFTRFGQKVVADENSWTLIPN
EAGVRGLPDSNKAAAASAARSRNLEGWAILNTRSAVDPFLTFADDRALREQVWKKFVNRG
DNGDANDTNATIAEIVKLRDQRAKLLGYRNHAELRMQDTMAKTPANAQALMDRVWAPAKA
RVAEEVADMKAIAGFDIEPWDYLYFAEKVRKAKYDLDQNQLKPYFELNAVRAGSFAMAER
LYGFQFKKLPKGSVPTFEPDVEAYEVYDKSRDGRLIGLYYTDDYARPGKRSGAWMTTYRS
FSQLDGSKVILASNNNNFTKPEPGEPVLISLDDAETLFHEFGHALHYLSSVVTYPSYGNT
PRDFVEYPSQVHEHWVLSRPILDGYLKHYQTGAAMPAELVNKIEAAATFNQGYATVSYLS
SAIVDMDLHTQAVPPTDIDAFEKASLARIGMPKEIVMRHRLPQFNHLFTSDAYSAGYYSY
LWSETMDADTWAYFEESGDVFNPDIAGRFKSIMLAPGNTTDRAEAYRAFRGRDPDVAALL
KVRGFPVS