Protein Info for A4249_RS12300 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: KpsF/GutQ family sugar-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 330 TIGR00393: sugar isomerase, KpsF/GutQ family" amino acids 53 to 313 (261 residues), 261.8 bits, see alignment E=4.1e-82 PF01380: SIS" amino acids 54 to 179 (126 residues), 93.3 bits, see alignment E=1.1e-30 PF00571: CBS" amino acids 219 to 265 (47 residues), 23.2 bits, see alignment 7e-09 amino acids 275 to 326 (52 residues), 35.7 bits, see alignment 9e-13

Best Hits

KEGG orthology group: K06041, arabinose-5-phosphate isomerase [EC: 5.3.1.13] (inferred from 76% identity to bsb:Bresu_0755)

Predicted SEED Role

"Arabinose 5-phosphate isomerase (EC 5.3.1.13)" in subsystem KDO2-Lipid A biosynthesis (EC 5.3.1.13)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I0H1 at UniProt or InterPro

Protein Sequence (330 amino acids)

>A4249_RS12300 KpsF/GutQ family sugar-phosphate isomerase (Brevundimonas sp. GW460-12-10-14-LB2)
MTEIAHSTPDDIAVMTDRAREVVRLNIEALEALERSIDVSLARAVDVIMSRPGYVVVTGM
GKSGHIGGKIAATLASTGTNAFFVHPAEMSHGDLGMLRPDVTVLAISNSGESRELRDPLI
YCQRNGIPVIAITQRPASFLGRNAAVCLTMPKVAEACPNGLAPTTSTLMTLALGDALAMV
LMDRREFTAMDFGLHHPGGALGMSLQSVREWMGDNAAVPASVPLNASFGDVVSAITEGRK
GAVAVLNADGALAGIVTDGDLRRAFQRDTTHLTAADIMGANPITVDPDARMSDVVDLLTA
NKIANLFVVEDGKPTAIVHIAELMQAGYVA