Protein Info for A4249_RS12160 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 transmembrane" amino acids 34 to 56 (23 residues), see Phobius details amino acids 232 to 254 (23 residues), see Phobius details PF13755: Sensor_TM1" amino acids 24 to 82 (59 residues), 49.1 bits, see alignment 7.9e-17 PF00672: HAMP" amino acids 253 to 303 (51 residues), 24 bits, see alignment 7.9e-09 PF00512: HisKA" amino acids 310 to 373 (64 residues), 52.1 bits, see alignment E=1.1e-17 PF02518: HATPase_c" amino acids 423 to 530 (108 residues), 92.5 bits, see alignment E=4.6e-30

Best Hits

KEGG orthology group: K14980, two-component system, OmpR family, sensor histidine kinase ChvG [EC: 2.7.13.3] (inferred from 71% identity to bsb:Bresu_0260)

Predicted SEED Role

"Sensor histidine kinase ChvG (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HYX2 at UniProt or InterPro

Protein Sequence (536 amino acids)

>A4249_RS12160 ATP-binding protein (Brevundimonas sp. GW460-12-10-14-LB2)
MASATATARAEPGGREPDEEPQRRPLFRFGGSRLGGFILVLNLLSLLILFGGALAINEWR
PGLIEARQESLTVQAELLANVLREEGVTRGEPTPELDPIRASIWLTDRFIPAGQRVRLYD
VNGLLLVDSYQVTEAIGGRPLPDAQPAGTATEDAARANLLSERRVARADSELAAEVAAAL
DGSPQSTLRRNESGDRVVSVSIPVRHVRQVLGVLTVESGDVDEILGAQRQALFPFALVAL
GVNLLGSLLLHLFVARPIMRLSAAADQVKLQRARAISLPDLEDRKDEIGDLARSLESMTD
TLSTRMDAIERFAADVSHEIKNPLTSIRSALETLPLVKTDAHREKLTALLQQDVRRLDRL
ITDISNASRLDAELSRDRPRPVDLNRLLVDIVGVYEATAKPGDIPVVLTAPEQALRVMGR
DGPLGQVFRNLIDNARSFSPPGGVVRVALEDIGDDLPIRVRVEDQGPGIPAENLETVFER
FYTSRPKGAVFGSNSGLGLSIVRQIVEAHGGRVHAENKSEGGARFEIVFPSVGRWS