Protein Info for A4249_RS11750 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1074 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 367 to 386 (20 residues), see Phobius details amino acids 393 to 414 (22 residues), see Phobius details amino acids 425 to 444 (20 residues), see Phobius details amino acids 475 to 493 (19 residues), see Phobius details amino acids 504 to 529 (26 residues), see Phobius details amino acids 572 to 591 (20 residues), see Phobius details amino acids 908 to 927 (20 residues), see Phobius details amino acids 934 to 953 (20 residues), see Phobius details amino acids 959 to 981 (23 residues), see Phobius details amino acids 1006 to 1026 (21 residues), see Phobius details amino acids 1037 to 1060 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1069 (1069 residues), 1321.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1059 (1054 residues), 916.4 bits, see alignment E=1.1e-279

Best Hits

Swiss-Prot: 52% identical to NCCA_ALCXX: Nickel-cobalt-cadmium resistance protein NccA (nccA) from Alcaligenes xylosoxydans xylosoxydans

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 86% identity to bsb:Bresu_1652)

MetaCyc: 51% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I096 at UniProt or InterPro

Protein Sequence (1074 amino acids)

>A4249_RS11750 CusA/CzcA family heavy metal efflux RND transporter (Brevundimonas sp. GW460-12-10-14-LB2)
MFKALIEASVRFRWFVVLATAIVAAFGLYNLTQLPIDAVPDITNRQVQINTIAPALAPEQ
MERQVTYPLETAMAGIPGIQTTRSLSRNGFSQVTVIFSDNTDIYFARQQVAERMAQARER
LPEGVEPALAPITTGLGEVLMWTVDFKPFNSANLAKPGEPGWQAGGAYLTPEGELLTTPQ
ARATYLRTVQDWIIAPRMRTAKGLAGVDVNGGYVKEYAVRPDAARLAGYGLSLNDLVVAL
ERANTQAGAGYVQRSGEALTVRTDALAQTIPDLAQAPVVNRNGLVVRVADVATVEIGQAP
RLGGASRDGHEAVVGTALMLAGGNSRTVAQAAAERLEEVSASLPPSVVAEPVLNRSSLVN
KTISTVAKNLIEGALLVIVVLFLLLGNIRAASITALMIPISFLFAVIGMNRFGISGNLMS
LGALDFGLLVDGAVVVVENTLLMLSQRRAEAGRMLTRRERLEVAGAAARQMVKPAAFGQL
IILLVFTPLLMLEGVEGKTFIPMGATVMLALVGAFIFSFTFVPAMTALLVRDPKKVEVDE
HGHAHEHETFILRYARRWIEPAIRAAVDRPKVVLASALGALVIGGIAFSSLGREFIPTLD
EGDIAMQALRVPSASLEQSLAMQMALERVIKAQPEVKTVFARTGTAEAAVDPMPPNISDA
VIVLKDRKEWPDPNLPKEELIERFEELAAGQLGNSFEFSQPIELRFNELISGVRTDLAVM
VYGDDFTQLQATADRVAAALRATPGSADVRVEQASGLPTLTVSVDRFAAANYGLSAADVS
EAVSAAVGGAEAGQIFEGDRRFSVVVRLADDARNDPAALAALPVTTATGVTVPLSSVARI
QVAEGQNQISRNDGSRRMVVQANVRGRDLGGFVTEAQAKVEADVDLPTGYSLTWGGQFEN
LKRAEQRLGLVIPIVFILIGVLLFMALGSFAEAGLVFACVPLALVGGALALVLRGMPFSV
SAAVGFIAVSGVATLNGLVLMQAIRERLTGGAAPRLAAIEGATSRLRAVLTTALVAIVGF
IPMAFAHGAGAEVQKPLATVVIGGLLTATALTLLVLPTFAAKAVKHRKAEGIEE