Protein Info for A4249_RS11495 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: response regulator transcription factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 217 PF00072: Response_reg" amino acids 4 to 112 (109 residues), 80.4 bits, see alignment E=1.1e-26 PF00486: Trans_reg_C" amino acids 148 to 216 (69 residues), 78.5 bits, see alignment E=3.3e-26

Best Hits

Swiss-Prot: 49% identical to QSEB_HAEIN: Transcriptional regulatory protein QseB (qseB) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: None (inferred from 60% identity to mea:Mex_2p1015)

Predicted SEED Role

"Two-component system response regulator QseB" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I0T7 at UniProt or InterPro

Protein Sequence (217 amino acids)

>A4249_RS11495 response regulator transcription factor (Brevundimonas sp. GW460-12-10-14-LB2)
MRLLAIEDDPVLADGLQVGLSACGWTVEVVGRVEDALAALESSAFDAVVLDLGLPDGDGL
SVLRFVRERDMDVGVVVLSARDDSRDRIVGLDAGADDYVGKPFDLDELAARLRAVRRRLL
GRSAPALRHGGVTLDPQSRLAWREEGDLPLSRREFAILEALMERPAQVLSRSQLEERLYG
WQEEIGSNAVEVHIHYLRAKLGAGFIRTVRGVGYTLQ