Protein Info for A4249_RS11290 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: double-strand break repair helicase AddA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1142 TIGR02784: double-strand break repair helicase AddA" amino acids 6 to 1130 (1125 residues), 1186.9 bits, see alignment E=0 PF00580: UvrD-helicase" amino acids 12 to 446 (435 residues), 152.9 bits, see alignment E=4.3e-48 PF13245: AAA_19" amino acids 14 to 68 (55 residues), 31.3 bits, see alignment 6.2e-11 PF13361: UvrD_C" amino acids 576 to 869 (294 residues), 48.7 bits, see alignment E=2.3e-16 PF12705: PDDEXK_1" amino acids 972 to 1115 (144 residues), 48.1 bits, see alignment E=4.7e-16

Best Hits

Predicted SEED Role

"FIG061771: ATP-dependent nuclease subunit A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HYI8 at UniProt or InterPro

Protein Sequence (1142 amino acids)

>A4249_RS11290 double-strand break repair helicase AddA (Brevundimonas sp. GW460-12-10-14-LB2)
MTAPSPQIIAADPRLTVFVTANAGSGKTTTLVNRVARLLLDQVDPGAILCVTYTKAAAAE
MQARLFDQLGGWAVLDDEELSKKVAKLDDGDPKTLDGQALSRARKLFARALETPGGLKIQ
TIHAFCEKLLRRFPLEAGVSPRFTVLEDQAATALSHAAREDLARAAVADPDGPIGQAYSH
FAVELDWQRFQALLSMIEAKRADLLDYIDRAEAGTAPDPWALTGAERDRSPEDLEQDFIA
WIDCAEWNRMAEAMETGSANDKKIADAMSVAAPPYAGFAALAGVFCTQAGEPRKSMGTKS
APQGAVGWLLDLQAKFLATREALRKAKVADDTVKVLTLARAHAAFYEAAKAQRGALDFPD
LVARAAALLTQSGAAAWVLYKLDGGVDHVLIDEAQDTAPEQWAIVRALTGEFYSGEKSGR
TVFAVGDEKQSIYSFQGARPERLRQERGAFLALAEGAGEPFAGPELNTSYRSTEEVLAFV
DAVFADPDRTRALTGPQGDIARHLPARIGQHGAIDLWPLFLDEPAPETDAWDDPVDQEGA
GSARKRLARDLAREIRRQVESGVAVFDRSTRDLRPAGYGDYIVLVRRRDATFEEIIRALK
TEGLPVAGADRLKLSSHIVFDDLISLARFALFPDDDLSLAEVLRSPLCDVDEDGLYALAG
RENRKAGQLWRDLRDRAHERPEWTRARDALQAAIGARGGDPFAFFSQALNRVDATGRSGR
ARILARLGREAEEAIDETLNQVLAAENRGAIDLETCLAQLEAADVEVKRELEGARGEVRV
MTVHGAKGLEAPIVILPDTTMKAKAQGPSLMPAVTPEGEGGAWLMAPGSAKDDCQASADA
RAARQARTDDETLRLLYVALTRARDRVIVMGRASSRGAEAGSWWSILEETFDRLGDQVRE
VENGVRRYGVDPERRPVAVDEIRLAAALPSWAASPPPADAAARFASPSRMEGGAIRIPAP
SPLANRAAGGASLGRFRRGDLVHRLLERLPEIAPADRPDAARRLLARETDLDEAQRAEMI
AAAFSVLDDARFAPVFGPGSRAEVALTGSAPDLPPGVAINGRIDRLVVTPEKVLVVDYKT
NRPAPDAVEAVDPAYVLQAAVYVAVLKRLYPDRSVEAALVWTDGPKLMPIPETLLAAALA
SS