Protein Info for A4249_RS10505 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: glutathionylspermidine synthase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03738: GSP_synth
  • amino acids 12 to 386 (375 residues), 493.9 bits, E=1.7e-152

Best Hits

Swiss-Prot: 49% identical to YGIC_ECO57: Putative acid--amine ligase YgiC (ygiC) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 74% identity to bsb:Bresu_2958)

MetaCyc: 49% identical to peptide--spermidine ligase YgiC (Escherichia coli K-12 substr. MG1655)
6.3.1.-

Predicted SEED Role

"Similarity with glutathionylspermidine synthase (EC 6.3.1.8), group 1" in subsystem Glutathionylspermidine and Trypanothione (EC 6.3.1.8)

MetaCyc Pathways

• glutathionylspermidine biosynthesis (1/1 steps found)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.1.8

Sequence Analysis Tools

See A0A160HZS2 at UniProt or InterPro

Protein Sequence (388 amino acids)

>A4249_RS10505 glutathionylspermidine synthase family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MERLRFDPRTDWDAKAEELGFTWRHTDGKPYWDETAAYAFSLAEIEDGIEAPTEELHGLC
LELVNEAVQSERLMEQLDIPETMRDYVADSWKRGDPSLYGRFDFAYDGTGPAKLYEYNAD
TPTSIYETAVFQWLWLEDQIKAGALPADADQFNSLHEKLVDRFRAIFPNGGFVHFASDAD
FVEDRQTVRFLEDLAQQAGLEPQFVAIDQIGLNADGRFVDHENWIIQAMFKLYPWEQMLR
DDYAAPLPTADVTVLEPAWKSILSNKAILPLLWQRHAGHPNLLESYFEGDPAEAALGSSY
VRKPLFSREGDNVELIDQGVSAAEVVDGGYGAGRHIRQALCDPPLFDGNHVIVGSWVVGT
EPAGISLREDTGRITRNTSRFVPHFIRD