Protein Info for A4249_RS10440 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: monovalent cation:proton antiporter-2 (CPA2) family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 620 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 35 to 53 (19 residues), see Phobius details amino acids 59 to 78 (20 residues), see Phobius details amino acids 90 to 112 (23 residues), see Phobius details amino acids 118 to 135 (18 residues), see Phobius details amino acids 156 to 180 (25 residues), see Phobius details amino acids 187 to 209 (23 residues), see Phobius details amino acids 222 to 241 (20 residues), see Phobius details amino acids 245 to 263 (19 residues), see Phobius details amino acids 275 to 296 (22 residues), see Phobius details amino acids 302 to 324 (23 residues), see Phobius details amino acids 336 to 358 (23 residues), see Phobius details amino acids 364 to 385 (22 residues), see Phobius details TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 17 to 291 (275 residues), 256.8 bits, see alignment E=1.4e-80 PF00999: Na_H_Exchanger" amino acids 17 to 379 (363 residues), 196.8 bits, see alignment E=5.3e-62 PF02254: TrkA_N" amino acids 411 to 524 (114 residues), 77.5 bits, see alignment E=1.1e-25

Best Hits

KEGG orthology group: K11747, glutathione-regulated potassium-efflux system protein KefB (inferred from 68% identity to pzu:PHZ_c0318)

Predicted SEED Role

"putative Glutathione-regulated potassium-efflux system protein KefB" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I0D7 at UniProt or InterPro

Protein Sequence (620 amino acids)

>A4249_RS10440 monovalent cation:proton antiporter-2 (CPA2) family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MAEATTGLDLGAAAALLAAGVLAVPVFKRIGLGSVLGYLAAGLAIGPFGLKLFREPETIL
HVAEFGVVIFLFIIGLEMRPKRLWGLRKEIFGLGAAQVLFCGLILTLTAMLAGFSAPVAF
VGAMGFVLSSTAVIMQMLEERGEIAGGPGQRAVSILLLEDLAIVPLLAIVAVLASVLGVA
NEQAPPLWQTVGFAVAAVGGVLLAGKYLVNPVFRLLAQYGGREVMTAAALLVVVGAAWAM
SLGGLSMAMGAFLAGVLLSESTFRHQLEADVEPFRAILLGLFFLSVGMSLDVSVVVADWR
LVLGGVVAFMLVKGVGIYAVARLFKASHHEAIERAGLFAQGGEFAFVLYGAAVAAGLFDA
RIGAMMSAVVILSMALTPLTSLLIARLSPKPVQDAESAEGVDFAKDLRGQVLIIGFGRFA
QVVSQPLLARDVDVSIIENDVEMIQAASQFGFKVYYGDGTQLHTLRASGAEEAEMVLVCV
DKPEAADRIVELVKSEFPTTRIMARAFDRGHSMRLIQAGVDYQIRETFESALKFGERALV
ELGLDEHEAAETIGDVRRRDEARLDLQLTGGLKAGRQLMRGNMPTPQPAPYIKPRREGRL
LNEDEAGPAAPDTRREPADT