Protein Info for A4249_RS09925 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: multidrug efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1092 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 344 to 363 (20 residues), see Phobius details amino acids 370 to 392 (23 residues), see Phobius details amino acids 398 to 420 (23 residues), see Phobius details amino acids 441 to 462 (22 residues), see Phobius details amino acids 473 to 500 (28 residues), see Phobius details amino acids 548 to 570 (23 residues), see Phobius details amino acids 883 to 904 (22 residues), see Phobius details amino acids 911 to 932 (22 residues), see Phobius details amino acids 939 to 963 (25 residues), see Phobius details amino acids 989 to 1008 (20 residues), see Phobius details amino acids 1021 to 1042 (22 residues), see Phobius details PF00873: ACR_tran" amino acids 3 to 1042 (1040 residues), 1101.2 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 4 to 1050 (1047 residues), 1156 bits, see alignment E=0 PF03176: MMPL" amino acids 322 to 502 (181 residues), 38.4 bits, see alignment E=7.3e-14 amino acids 842 to 1046 (205 residues), 24.8 bits, see alignment E=1e-09

Best Hits

KEGG orthology group: None (inferred from 78% identity to bsb:Bresu_3098)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I079 at UniProt or InterPro

Protein Sequence (1092 amino acids)

>A4249_RS09925 multidrug efflux RND transporter permease subunit (Brevundimonas sp. GW460-12-10-14-LB2)
MNISRFFIDRPIFAAVIAVVMSIIGIAAYPLLPLSQYPEIAPPTITINAAYPGASAETLA
ETVAAPIEQEVNGVENMLYISSSSTSDGAVAITVTFQPGTDLDSAQVLVQNRVALAEPRL
PEAVRQTGVVVNKAESGFLMILGLTSPDGALDNDYIGNYANSTLRDRLLRIEGVGAVQVF
GGGNYSMRVWIDPAKAAERGLTGPEIVSALRAQNVQAAAGSIGQPPFPNSAAAFQLPVQV
QGRLSDPNEFANVVLKTDAQGRVTYLRDVARIELGAQDYGIRGFFDGQRGVGIAIVQQPG
ANALGTADRVLKEVEALKSEVPAGMKVDVPYNPTEFVAASVESVQHTLVEAVILVIIVVM
VFLQTWRAAIIPIVAIPVALVGTFAVQLALGYSINSLSLFALVLAVGIVVDDAIVVVENV
ERAIGEGLSPKEAAYRSMQEVSGALIAIGLVLVSVFVPTMFVPGIPGIFYRQFAVVIASA
SVISLFVSLTLSPAMAALLLKPHKKDHEHARKPGILGTVVYYGGWAGRKFNDGFDWLSDR
YGRLTARLVRTVGLVLIIYAGLLGLTAWRLVDTPSGFIPEQDQGFLIGVIQLPAGASLDR
TQAVMERATKIIQGTAGVNGTVAFAGLDGSSFSFGSNAATIFVRLNGFEERSKEEAATAL
AGAITQATGQIEDAQIFVIAPPAVQGLGTGNGFSMMIQDREGAGYRPLEGATFAMMGAAA
QKPTEVSQVFSTYNTASPRITADVDRDKALMLGVQPSSVFDTLGVYLGSSYVNDFNMLGR
TFRVTAQAEPTARDDIADIANLKTKSSTGAMVPIGSVANLVNDSGPARIVRYNLFPAAEL
QGNAAAGVSSGEALQIMETMAAQTLPQGFSYEWTGLAYQQKAAGSGATVIFLMAVVFVFL
VLAAQYEAFTLPLAVILIVPMCLLAAIIGVNLRGLDNNILVQIGLVVLIALAAKNAILIV
EFAKQAEEEQGMNRFEAAVAAAKTRLRPILMTSFAFILGVVPLMLASGPGAEMRQSLGTS
VFSGMLGVTFFGLIFTPVFYVVSRWLSSKLPQGKKPTPTPDRPSDRPVHYDETSDLTDPN
APAPATGRGGDI