Protein Info for A4249_RS09870 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: UDP-3-O-acyl-N-acetylglucosamine deacetylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00325: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
  • amino acids 9 to 290 (282 residues), 322.6 bits, E=1.3e-100
• PF03331: LpxC
  • amino acids 10 to 280 (271 residues), 342.3 bits, E=1.1e-106

Best Hits

Swiss-Prot: 66% identical to LPXC_PHEZH: UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC) from Phenylobacterium zucineum (strain HLK1)

KEGG orthology group: K02535, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC: 3.5.1.-] (inferred from 85% identity to bsb:Bresu_2685)

MetaCyc: 45% identical to UDP-3-O-acyl-N-acetylglucosamine deacetylase (Vibrio cholerae O1 biovar El Tor str. N16961)
RXN-23222 [EC: 3.5.1.108]

Predicted SEED Role

"UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EC 3.5.1.108)" (EC 3.5.1.108)

MetaCyc Pathways

• lipid IV_A biosynthesis (E. coli) (6/6 steps found)
• lipid IV_A biosynthesis (P. gingivalis) (8/9 steps found)
• superpathway of (Kdo)₂-lipid A biosynthesis (13/17 steps found)
• lipid IV_A biosynthesis (H. pylori) (5/6 steps found)
• lipid IV_A biosynthesis (P. putida) (5/6 steps found)
• lipid IV_A biosynthesis (Vibrio cholerae serogroup O1 El Tor) (5/6 steps found)
• lipid IV_A biosynthesis (generic) (5/6 steps found)
• lipid IV_A biosynthesis (2,3-diamino-2,3-dideoxy-D-glucopyranose-containing) (4/6 steps found)
• superpathway of Kdo₂-lipid A biosynthesis (13/25 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Caprolactam degradation
• Glutathione metabolism
• Lipopolysaccharide biosynthesis
• Lysine biosynthesis
• Nicotinate and nicotinamide metabolism
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.-

Use Curated BLAST to search for 3.5.1.- or 3.5.1.108

Sequence Analysis Tools

See A0A160HZI7 at UniProt or InterPro

Protein Sequence (299 amino acids)

>A4249_RS09870 UDP-3-O-acyl-N-acetylglucosamine deacetylase (Brevundimonas sp. GW460-12-10-14-LB2)
MSVRSDHHERTIVAPAIIAGVGVHTGRRVRLAVRPAPSGTGIVFVRTDITDRDNRIPVSG
EAVVDARLNTMIENGAGVRLSTIEHLMAAFAALGVSNAVVEVDGPELPILDGSALEFVKL
LDRAGFRPQPTPQRYIEILETVHVVEGDKHAALMPCDRYEMRFEIDFPSAVIGNQVIDFV
VDEPTFRKEIMACRTFGFAHEVEALRKAGLARGGSLENAVVIDGDEILNPGGLRMEREFV
RHKALDAIGDLYVLGAQLLGRYEGYKAGHALNNKLVRALLAAPHAWREVTRVPELARAG