Protein Info for A4249_RS09690 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: 1-deoxy-D-xylulose-5-phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13292: DXP_synthase_N
  • amino acids 8 to 282 (275 residues), 385.6 bits, E=2.5e-119
• TIGR00204: 1-deoxy-D-xylulose-5-phosphate synthase
  • amino acids 10 to 626 (617 residues), 777.1 bits, E=6.5e-238
• PF02779: Transket_pyr
  • amino acids 319 to 479 (161 residues), 142.5 bits, E=2.3e-45
• PF02780: Transketolase_C
  • amino acids 496 to 619 (124 residues), 102.2 bits, E=3.8e-33

Best Hits

Swiss-Prot: 82% identical to DXS_CAUSK: 1-deoxy-D-xylulose-5-phosphate synthase (dxs) from Caulobacter sp. (strain K31)

KEGG orthology group: K01662, 1-deoxy-D-xylulose-5-phosphate synthase [EC: 2.2.1.7] (inferred from 86% identity to bsb:Bresu_2791)

MetaCyc: 56% identical to 1-deoxy-D-xylulose 5-phosphate synthase (Arabidopsis thaliana col)
1-deoxy-D-xylulose-5-phosphate synthase. [EC: 2.2.1.7]

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7)" in subsystem Isoprenoid Biosynthesis or Pyridoxin (Vitamin B6) Biosynthesis or Thiamin biosynthesis (EC 2.2.1.7)

MetaCyc Pathways

• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (12/12 steps found)
• taxadiene biosynthesis (engineered) (12/13 steps found)
• methylerythritol phosphate pathway I (9/9 steps found)
• methylerythritol phosphate pathway II (9/9 steps found)
• isoprene biosynthesis I (9/10 steps found)
• superpathway of thiamine diphosphate biosynthesis II (9/11 steps found)
• pyridoxal 5'-phosphate biosynthesis I (6/7 steps found)
• thiazole component of thiamine diphosphate biosynthesis II (5/7 steps found)
• superpathway of thiamine diphosphate biosynthesis I (7/10 steps found)
• thiazole component of thiamine diphosphate biosynthesis I (3/6 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (7/12 steps found)
• superpathway of ergosterol biosynthesis II (11/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.2.1.7

Sequence Analysis Tools

See A0A160I049 at UniProt or InterPro

Protein Sequence (637 amino acids)

>A4249_RS09690 1-deoxy-D-xylulose-5-phosphate synthase (Brevundimonas sp. GW460-12-10-14-LB2)
MMPDTPLLDTVKTPADTRDFDIAQLKQLAQEVRAETIDAVSVTGGHLGAGLGVVELTTAL
HHVFETPKDILIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHA
STSISAALGFAAARDQKGEKNRVVAVIGDGSMSAGMAYEAMNNAAEATSGQLMVILNDND
MSIAPPVGGMSAYLAGLVSGGAYQNVRRLGKTVAQHLPRPFRKAAKKAEEYARGMVTGGT
FFEELGFYYVGPIDGHDMDNLVPILKKAAAIEDRPVLVHVVTQKGKGYAPAESSADKLHA
VVKFDVVSGKQAKAISNAPSYTKVFGTELIKHAKVDPSIVAITAAMPSGTGLDLFGQAFP
ERTYDVGIAEQHAVTFAAGLAADGMKPVCAIYSTFLQRGYDQVVHDVAIQSLPVRFAMDR
AGLVGSDGATHAGSFDIGFMGALPGMVLMAAADEAELAAMISTSLAIDDRPSAFRYPRGD
GVGVEIPELPAPLEIGKGRIVREGTSVAILSLGTRLQESLKAADMLAARGVSATVADARF
AKPLDADLILRLAREHEALITVEEGAMGGFGAFVLQLLAEKGALDGGLKIRTLNLPDVFQ
DQDAPMAMYAQAGLNAEHITAAALQALGVSASQAVRA