Protein Info for A4249_RS09255 in Brevundimonas sp. GW460-12-10-14-LB2
Annotation: phosphoribosylamine--glycine ligase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 65% identical to PUR2_PHEZH: Phosphoribosylamine--glycine ligase (purD) from Phenylobacterium zucineum (strain HLK1)
KEGG orthology group: K01945, phosphoribosylamine--glycine ligase [EC: 6.3.4.13] (inferred from 82% identity to bsb:Bresu_1848)Predicted SEED Role
"Phosphoribosylamine--glycine ligase (EC 6.3.4.13)" in subsystem De Novo Purine Biosynthesis (EC 6.3.4.13)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
- superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.3.4.13
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A160HZA4 at UniProt or InterPro
Protein Sequence (424 amino acids)
>A4249_RS09255 phosphoribosylamine--glycine ligase (Brevundimonas sp. GW460-12-10-14-LB2) MNILLVGSGGREHALAWKIAQSPLVTRLVAAPGNPGIEKLCELRAVKADDADGLAALARE IKADLVVVGPEVALAAGLADRLASAGIPCFGPTAKAAQLETSKAFSKGFLERHEIPTAGY GVYDTVKDAKAALDVFRPPYVIKADGLAAGKGVAISPDRPDAEAEIERMLGGRFGAAGAR VVIEEFMDGEEGSLFALCDGQRALLFGGAQDHKRAYDGDLGPNTGGMGAYSPAPVFTPEL VQQADALIVQPTIRKMAEEGAPYRGVLYAGLMATEDGPKVVEFNARFGDPECQVLMMRMA GDIVPYLLGCARGDVSGLASPAFKPQTVICVVMAAKGYPDSPLEGSIIRGADQDFGPHVQ VFHAGTKRRDDGLLAASGGRVLNVCAEGDDIAQARERAYAAIRKIDWPGGFNRSDIGWRA LDRG