Protein Info for A4249_RS09035 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: redox-regulated ATPase YchF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00092: GTP-binding protein YchF
  • amino acids 1 to 364 (364 residues), 469.5 bits, E=3.8e-145
• PF01926: MMR_HSR1
  • amino acids 4 to 121 (118 residues), 82.3 bits, E=4.3e-27
• PF02421: FeoB_N
  • amino acids 4 to 48 (45 residues), 35 bits, 1.5e-12
• PF06071: YchF-GTPase_C
  • amino acids 281 to 364 (84 residues), 129.5 bits, E=6.1e-42

Best Hits

Swiss-Prot: 58% identical to YCHF_HAEIN: Ribosome-binding ATPase YchF (ychF) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K06942, (no description) (inferred from 86% identity to bsb:Bresu_2673)

MetaCyc: 57% identical to redox-responsive ATPase YchF (Escherichia coli K-12 substr. MG1655)
Nucleoside-triphosphatase. [EC: 3.6.1.15, 3.6.1.5]

Predicted SEED Role

"GTP-binding and nucleic acid-binding protein YchF" in subsystem Universal GTPases

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism
• Thiamine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.15

Use Curated BLAST to search for 3.6.1.15 or 3.6.1.5

Sequence Analysis Tools

See A0A161IIP0 at UniProt or InterPro

Protein Sequence (364 amino acids)

>A4249_RS09035 redox-regulated ATPase YchF (Brevundimonas sp. GW460-12-10-14-LB2)
MALKVAIVGLPNVGKSTLFNALTKTAAAQAANYPFCTIEPNTGDVAVPEARLNALAEIAG
SKEIIPARITFVDVAGLVRGASKGEGLGNQFLANIRDCDAVAFVARCFVDDDITHVEDRI
DPIADLEIIETELMLADMESLERRRPQLEKRAKGGDKESALTLKLVDLALAQLNAGKPAR
TAEVSKEDIKAWHMLQLLTALPALYVSNVEEGSADKGNDLSDKVAARAAQDNANSVVISA
QIESEIAVLDDEEQKQFLETLGLEEPGLNRLIREAYKLLGLHTYFTVGPKEARAWTINVG
DTAPQAAGVIHTDFEKGFIRAETIAFDDFVALRGEAKAREAGKLRAEGKSYVVKDGDVMN
FLFN