Protein Info for A4249_RS08995 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 transmembrane" amino acids 18 to 38 (21 residues), see Phobius details amino acids 43 to 61 (19 residues), see Phobius details PF00512: HisKA" amino acids 211 to 275 (65 residues), 62.6 bits, see alignment E=4.5e-21 PF02518: HATPase_c" amino acids 323 to 461 (139 residues), 86.2 bits, see alignment E=3.3e-28

Best Hits

KEGG orthology group: K07636, two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC: 2.7.13.3] (inferred from 74% identity to bsb:Bresu_1698)

Predicted SEED Role

"Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HXU6 at UniProt or InterPro

Protein Sequence (465 amino acids)

>A4249_RS08995 ATP-binding protein (Brevundimonas sp. GW460-12-10-14-LB2)
MPYEVSPSPVAPVSTSRLWTVGASIGIAIVTLLVLAVLHPELANWLVGGAVIVAASAWLL
NMNEAARAEPAASQGAATEPAIDMVTGDLLDRVFEALDDPVLVVSGGEPDDIAGRRIVMA
NAAARELLRIQRQGALLVQVIREPGVLEAVDEALFGGTARTTDYATGGQRDRRWRAWTRP
LSLEASGKTGSELALLMLRDETDSRRIEMMRVDFLANASHELRTPLASLSGFIETLKGHA
REDVVARDRFLDIMSAQADRMGRLVADLLSLSRIELNEHIPPSGRVDLDRAASDVVDAIS
VLTREKEIAIALDQGEARASISGDRDEILQVVQNLLDNAVKYSSRNGTVEISVRSDLSFD
EAWASRMPGATRLPLVTPDRTAGVSYAAVTVRDHGPGMAREHLPRLTERFYRVEGQKSGE
RQGTGLGLAIVKHIINRHQGGLVVESAPGMGAAFTAWFPQPIERR