Protein Info for A4249_RS08705 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 540 PF00512: HisKA" amino acids 159 to 224 (66 residues), 62.5 bits, see alignment E=4.6e-21 PF02518: HATPase_c" amino acids 272 to 378 (107 residues), 82.9 bits, see alignment E=3.5e-27 PF00072: Response_reg" amino acids 406 to 517 (112 residues), 95 bits, see alignment E=4.8e-31

Best Hits

KEGG orthology group: None (inferred from 76% identity to bsb:Bresu_2341)

Predicted SEED Role

"sensor histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168NK62 at UniProt or InterPro

Protein Sequence (540 amino acids)

>A4249_RS08705 response regulator (Brevundimonas sp. GW460-12-10-14-LB2)
MPTIETLSERPKPVAPTTLGCEVLARFECEPDTLVIPVVDGDRPVGLVERTAFLQKIAAR
FGHALYDLRPITFAMDPEPAVVEAGVRIDAFCDIMLKGGPAALLRGFIVTKNGAYWGVGT
AATLLQAVNTRQREQNAELAEQAAILSDTRAQAIAAARAKSQFLAIMSHELRTPMNGVLA
VAELLRRQPLNTAAQAHVQTIVDSSETLLRILQDAVDLSKAEAGELELKTEPTALRAVMD
DIQSMWEPRASQDGVTLLVGYEGDTELAAVIDGVRLKQVFNNLIGNALKFARNGVVEAGL
KAWVEGDRIRMEARIRDDGPGVEPDRVDSIFEPFVHGSGPDGAGLGLSICRQVIDRMDGR
IWAENNKGRGATFAFDLTAPRAVVEAEAQSNVSDLSGLDLKSAPHILIVDDNATNRVVAQ
ALCEMFGCSSELAEDGLEALQAVQESRYDLVLMDIKMPRMDGVQATQAIRALPGAVGRVP
IVALTANADPEDAKHYLSIGMAAVVEKPIKPERLRMAMNAAISAAHEDAQDQDQSGRAVA