Protein Info for A4249_RS08225 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: M13 family peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 694 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF05649: Peptidase_M13_N" amino acids 65 to 438 (374 residues), 393.6 bits, see alignment E=1.3e-121 PF01431: Peptidase_M13" amino acids 490 to 689 (200 residues), 224.3 bits, see alignment E=1.3e-70

Best Hits

KEGG orthology group: K07386, putative endopeptidase [EC: 3.4.24.-] (inferred from 68% identity to bsb:Bresu_2219)

Predicted SEED Role

"Metallopeptidase"

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HXJ1 at UniProt or InterPro

Protein Sequence (694 amino acids)

>A4249_RS08225 M13 family peptidase (Brevundimonas sp. GW460-12-10-14-LB2)
MTRIRLMAACSACIVVALTGGAASAQDASAQNASDQHSHGMAGAAHSPFGAWGFDLAGRD
TSVKPGDDFNEYANGTYLRTTEIPADKSRFGPFDVLYENAQSQLKSIIETSAANPANENA
RKVGALYASFMDEAKIEQLGATPLAADLAAVKAVTDHAGMARLMGESHSGFGGSLFGIDV
FEDLKNPNLNSAYLGQGSLGLPDRDYYLKPDFAAQREAYLAYLTTTLTAIGWADPAKTAA
DILAFETKVADKQWTTVERRQIDKLYNPAKASDLATLAPGFDWAGFLSGAQVSDVDTLVL
MENTAIPATAQVFADTPIETLKAWQAFNVVDQATPYLSKAFVDARFDFRGKTLRGQPENR
PRWNRGVALVDGQLGEVLAQEYVRLHFPASSKAQMEALVGNIRDAMTERLKTLDWMSEPT
REQALYKMSKFGVKIGYPDKWRSYDGLELKTDDLYGNVERSSAFEWAYKRGKIGMPVDPL
EWGMTPQTVNAYYNPPRNEIVFPAAILQAPFFDPNADPAVNYGGIGAVIGHEITHGFDDQ
GRKSDGDGVLRDWWTPEDAARFEARAKVLGDIYDKLEPIPGVHVNGDLTMGENIADLGGL
LLALDAYHKSLNGQPAPVIDGLTGDQRVFLGWAQVWREKSREAALKEQLTTDPHSPGPVR
AATSPRNIDAWYAAFGVSPDQKEYIAPEARARIW