Protein Info for A4249_RS07780 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1068 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 356 to 375 (20 residues), see Phobius details amino acids 382 to 402 (21 residues), see Phobius details amino acids 409 to 432 (24 residues), see Phobius details amino acids 453 to 474 (22 residues), see Phobius details amino acids 484 to 503 (20 residues), see Phobius details amino acids 548 to 571 (24 residues), see Phobius details amino acids 878 to 897 (20 residues), see Phobius details amino acids 906 to 926 (21 residues), see Phobius details amino acids 932 to 956 (25 residues), see Phobius details amino acids 977 to 998 (22 residues), see Phobius details amino acids 1009 to 1035 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 3 to 1035 (1033 residues), 915 bits, see alignment E=8.6e-279 PF03176: MMPL" amino acids 318 to 509 (192 residues), 25.7 bits, see alignment E=8.1e-10 amino acids 851 to 1042 (192 residues), 24.4 bits, see alignment E=2e-09 PF02355: SecD_SecF" amino acids 348 to 504 (157 residues), 20.9 bits, see alignment E=3.1e-08

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 83% identity to bsb:Bresu_1487)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I115 at UniProt or InterPro

Protein Sequence (1068 amino acids)

>A4249_RS07780 efflux RND transporter permease subunit (Brevundimonas sp. GW460-12-10-14-LB2)
MLSDVSVRRPVFAAVAAIVLCVIGAAAFFFLPVRELPDVDPPIVSVNTSYAGASAEVIES
RITEPVEQQIAGIQGVERINSTSRDGRSNVNIEFSLDRNIDDAANDVRDRVSRVVGRLPD
QADPPEVAKADSDSQPIIIVFLRSTSMNRLQLTDYADRYLIDRMATVPGVAQVNIYGEQR
YSMRIWLDSAAMAARGLTVNDVETALTNQNVELPAGSLESTDKDYTVRVARTYALPEDFR
QLPIGTRGSASASATVATGTGSGSSAIIQGQPTYVTRLGDIARVEEAPEEDRRLFRGNGM
DQIGLAVTRQAQSNDLAISDGVHKMIEEIRPTLPPGVTIEVGSDNSVFTSHAIDEVWITI
GISMALVALVNFIFLGSLRAALIPSIVAPICLLATFIVLAPLGFSLNLLTLLALVLAIGL
VVDDAIVVVENIQRRLDLGEPPLVAAERGARQVFFAVVATTIVLLSVFAPLLFLPGYVGR
LFVELAAAIAAAVAFSAFLALSLSPMLASKILRPAHGGGWVARKVDWGMDRLKSSYGRSL
DMLLGRRIAVIGVGALILLVAAGAGGIFLTLPNELVPDEDRGRVTVRVAGPEGAGFDYTR
KIMLGLEPLLAEYKTSGEADSYLVSAPGFGGGSFNSGNAVLTLADWSKRDRSAAEIAQEL
NGKLRGQTGAQVNASTPGAFQRGGGNSNSIELIATGSDYQQIYAWLQPMLAAAQANPGFS
RPRLNYEPNSPRLLVDVDPQKAAALGVSSQSIGRTLETMFGSRRATTYIKGGQEYDVILQ
TERDNRREVADLEALYVATGGGQLVPLSAVVTTKTSGDTPDRRRLDRQRAISLQADLNPG
TTIDDAIQFLNAEAAKQPQGAVVTQWGGAARDQQEAGGAVFAAFGLALLLVFLVLAAQFE
SWITPAVIMLTVPLAAAGGLFGLLMAGSSLNIYSQIGLIILIGVAAKNGILIVEFANQLR
DQGRSIREAIIESSSLRLRPIIMTSIATAFGALPLVLWQGAGAGSRQTIGVVIFTGAIFA
TVLTLFVVPVIYGVLARFTKSPEWTARKIEEWEAKELREGGPKELPEA