Protein Info for A4249_RS07705 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: SDR family NAD(P)-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08659: KR
  • amino acids 12 to 162 (151 residues), 31.5 bits, E=2.4e-11
• PF00106: adh_short
  • amino acids 12 to 200 (189 residues), 185.7 bits, E=1.1e-58
• PF13561: adh_short_C2
  • amino acids 19 to 247 (229 residues), 182 bits, E=2.2e-57

Best Hits

Swiss-Prot: 81% identical to KDRDH_SPHSS: 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+)) (LRA5) from Sphingomonas sp. (strain SKA58)

KEGG orthology group: K00059, 3-oxoacyl-[acyl-carrier protein] reductase [EC: 1.1.1.100] (inferred from 81% identity to cse:Cseg_1772)

MetaCyc: 81% identical to L-2-keto-3-deoxyrhamnonate 4-dehydrogenase subunit (Sphingomonas sp. SKA58)
RXN-12095 [EC: 1.1.1.401]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 1.1.1.100)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (49/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (18/20 steps found)
• oleate biosynthesis IV (anaerobic) (13/14 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• (5Z)-dodecenoate biosynthesis I (6/6 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (8/9 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• L-rhamnose degradation III (6/7 steps found)
• (5Z)-dodecenoate biosynthesis II (5/6 steps found)
• stearate biosynthesis II (bacteria and plants) (5/6 steps found)
• cis-vaccenate biosynthesis (4/5 steps found)
• fatty acid elongation -- saturated (4/5 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (9/12 steps found)
• palmitate biosynthesis III (21/29 steps found)
• 8-amino-7-oxononanoate biosynthesis I (8/11 steps found)
• stearate biosynthesis IV (4/6 steps found)
• anteiso-branched-chain fatty acid biosynthesis (24/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (24/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (24/34 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (3/5 steps found)
• tetradecanoate biosynthesis (mitochondria) (17/25 steps found)
• L-arabinose degradation V (2/6 steps found)
• petroselinate biosynthesis (2/6 steps found)
• biotin biosynthesis I (8/15 steps found)
• 2-allylmalonyl-CoA biosynthesis (2/8 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• mycolate biosynthesis (26/205 steps found)
• superpathway of mycolate biosynthesis (27/239 steps found)

KEGG Metabolic Maps

• Biosynthesis of unsaturated fatty acids
• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100

Use Curated BLAST to search for 1.1.1.100 or 1.1.1.401

Sequence Analysis Tools

See A0A160HZA5 at UniProt or InterPro

Protein Sequence (250 amino acids)

>A4249_RS07705 SDR family NAD(P)-dependent oxidoreductase (Brevundimonas sp. GW460-12-10-14-LB2)
MSAYQGRFTGRTAVVTGGASGLGKAAASRIVAEGGKVVLWDLNAEALTAAAAEVGAAHVI
ALDVADPDAVAAAADASAQALDGRIDILIASAGITGATVPVHEFPIDSWKRVVDINLNGV
FYCSRAIVPFMLANGYGRIVNVASVAGKEGNPNASAYSASKAGVIGFTKSLGKELAGKGV
VANSLTPATFESPILEQLPQSQVDYMRSKIPMGRLGEVEESAAMVCFMASEECSFTTAST
FDTSGGRTTY