Protein Info for A4249_RS06730 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: leucyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 491 transmembrane" amino acids 359 to 379 (21 residues), see Phobius details PF02789: Peptidase_M17_N" amino acids 16 to 137 (122 residues), 79.6 bits, see alignment E=2e-26 PF00883: Peptidase_M17" amino acids 175 to 481 (307 residues), 415.6 bits, see alignment E=1.3e-128

Best Hits

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 70% identity to bsb:Bresu_2579)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.1

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HWZ3 at UniProt or InterPro

Protein Sequence (491 amino acids)

>A4249_RS06730 leucyl aminopeptidase (Brevundimonas sp. GW460-12-10-14-LB2)
MKIEFVAAVDAAEILAVPIFEDRTFTAAGTALDGKANGALTKAAGKGRFTGKAGQSLSIA
APAGVEADVVLLVGAGAKDKLDDLAVEAFGGNAYAAVKLSGAEVLTIDASDLSPEQAARV
GFAARLAAYRFDKYRTTQKADKIPSITTIRVVTTDLRGAEAALEPLSAVADGVIFARDLV
SEPANVLYPAEFAKRVKALESLGLEVEILGEAEMEKLGMRTLLGVGQGSRRESQLAIMKW
NGGEAGAQPLAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVTGTMIALASRKAKAN
VIGVLGLVENMPDGNAQRPGDVVVSMSGQTVEVINTDAEGRLVLADALWYTQERFKPKFM
IDLATLTGAMIVALGLDYAGVFSNSDDVADPILSAAKKVGENFWRMPIPAIYEQHIDSKI
ADVKNTGNGRAGGSITAALFLQRFTNGVPWAHLDIAPTAWANKSPSPTVPEGGVGFAVRT
LDRMVADSYEG