Protein Info for A4249_RS06620 in Brevundimonas sp. GW460-12-10-14-LB2
Annotation: N-formylglutamate deformylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01479, formiminoglutamase [EC: 3.5.3.8] (inferred from 68% identity to pzu:PHZ_c0467)Predicted SEED Role
"N-formylglutamate deformylase (EC 3.5.1.68)" in subsystem Histidine Degradation (EC 3.5.1.68)
MetaCyc Pathways
- L-histidine degradation II (5/5 steps found)
- L-histidine degradation I (4/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 3.5.1.68
Use Curated BLAST to search for 3.5.1.68 or 3.5.3.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A160HWX7 at UniProt or InterPro
Protein Sequence (272 amino acids)
>A4249_RS06620 N-formylglutamate deformylase (Brevundimonas sp. GW460-12-10-14-LB2) MQDWLTIHEGTAPLVIGLPHTGTDIPTAIEARMTSSWLARKDADWWVDRLYDFAIDMGAT LVRTGVSRSVIDVNRDPSGVSLYPGMTTTGLCPTETFDGEPLYRPGQEPNPAEIAERRAI WFDPYHAALQGQLDRLRSAGPVVLYDAHSIRSVVPRLFEGELPQFNIGDNDGSTCAGDLT QAVEKACTISSDSVVVNGRFKGGWTTRHYGQPDAGVHAIQMELADRGYILDPAGPVSSDN WPSLYEPDRAEPMRGHMRRVLTACIAFAESQR