Protein Info for A4249_RS06500 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: trigger factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 PF05697: Trigger_N" amino acids 1 to 149 (149 residues), 115.5 bits, see alignment E=3.8e-37 TIGR00115: trigger factor" amino acids 12 to 425 (414 residues), 420.4 bits, see alignment E=3.7e-130 PF00254: FKBP_C" amino acids 164 to 245 (82 residues), 64.3 bits, see alignment E=1.6e-21 PF05698: Trigger_C" amino acids 268 to 425 (158 residues), 151.6 bits, see alignment E=3e-48

Best Hits

Swiss-Prot: 60% identical to TIG_CAUVC: Trigger factor (tig) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K03545, trigger factor (inferred from 82% identity to bsb:Bresu_1741)

Predicted SEED Role

"Cell division trigger factor (EC 5.2.1.8)" in subsystem Bacterial Cell Division (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HWU2 at UniProt or InterPro

Protein Sequence (448 amino acids)

>A4249_RS06500 trigger factor (Brevundimonas sp. GW460-12-10-14-LB2)
MQVVEKSNEGLSRVIAVTIPVAELNEKLEARVKEVAPQVKLKGFRPGKVPVAHVKKTFGR
EFMGEIINAELNETSQKALDEAKIRPAAPAEMKLTSDMDKVIAGQEDLAYEMSLEIMPDF
EPVDPKTLKLERPTYEASDADLDEALTELAGQAKTYEDKKGKTVKAAEGDQLTIDFLGKL
DGEPFEGGAAEDADLVIGSGRFIPGFEEQLTGAKVGEEKTIEVTFPENYQAAHLAGKKAT
FDIKVKAIKAEAESKIDDDFATRIGLESLDKLKELLKSNLDQQYAGAARFKLKRALLDQL
DEAHDFPLPPKMVDAEFDGIWQQVEADKTAGRLPEEDAAKSDEDLKAEYRKIAERRVRLG
LVLAEIGRANNVQVTDQELNAAILQEARNYPGQEQAVLNFYRQNPNAAAQMRAPIYEEKV
VDLIVGVADVTDKPITKEELLKEDEDEG