Protein Info for A4249_RS06490 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: ATP-dependent Clp protease proteolytic subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 215 transmembrane" amino acids 38 to 59 (22 residues), see Phobius details amino acids 98 to 115 (18 residues), see Phobius details PF00574: CLP_protease" amino acids 22 to 201 (180 residues), 271.6 bits, see alignment E=1.7e-85

Best Hits

Swiss-Prot: 84% identical to CLPP_CAUVC: ATP-dependent Clp protease proteolytic subunit (clpP) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K01358, ATP-dependent Clp protease, protease subunit [EC: 3.4.21.92] (inferred from 93% identity to bsb:Bresu_1743)

MetaCyc: 60% identical to ATP-dependent Clp protease proteolytic subunit (Escherichia coli K-12 substr. MG1655)
Endopeptidase Clp. [EC: 3.4.21.92]

Predicted SEED Role

"ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent or cAMP signaling in bacteria (EC 3.4.21.92)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.92

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HYT1 at UniProt or InterPro

Protein Sequence (215 amino acids)

>A4249_RS06490 ATP-dependent Clp protease proteolytic subunit (Brevundimonas sp. GW460-12-10-14-LB2)
MRDPIELMNMNLVPMVVEQSSRGERSFDIFSRLLRERIIFLTGPFEDGMASLICAQLLFL
ESENPKKEISMYINSPGGQVTSALAIYDTMQYIKSPVSTVVMGMAASAGSLILTAGEAGQ
RIALPNARVMVHQPSGGFRGQASDIELHAADIRYTKRRLNEIYVHHTGRTYEEVEKTLDR
DHFMSADEAKAWGIVDHVYDRREQADADGVKTPGN