Protein Info for A4249_RS06480 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: HAD-IB family hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 215 transmembrane" amino acids 46 to 63 (18 residues), see Phobius details PF00702: Hydrolase" amino acids 20 to 203 (184 residues), 41.7 bits, see alignment E=1.8e-14 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 21 to 203 (183 residues), 106.9 bits, see alignment E=1.2e-34 TIGR01490: HAD hydrolase, family IB" amino acids 21 to 211 (191 residues), 148.6 bits, see alignment E=2.8e-47 PF12710: HAD" amino acids 21 to 200 (180 residues), 116.4 bits, see alignment E=2.2e-37

Best Hits

Swiss-Prot: 56% identical to CICA_CAUVN: Protein CicA (cicA) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: None (inferred from 60% identity to bsb:Bresu_1746)

Predicted SEED Role

"cicA protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HY39 at UniProt or InterPro

Protein Sequence (215 amino acids)

>A4249_RS06480 HAD-IB family hydrolase (Brevundimonas sp. GW460-12-10-14-LB2)
MSDMGIVQEIRQSTGNGPAIVAFDFDGTLTIRDSFTEFLRWRSGPGAWALGLVKLAPALA
AYAKDRDRGRIKAASVKEFLLGVSRQTLEAEAAAFAEEIWPRFMRPDALEVWNDWGQRGA
HRVIVTASPTTTVAPFARKLGAEALLGTEFVFDADDRITGDFAGPNCRGQEKVRRLKAAY
GEDMTLTAAYGDTSGDTEMLAMAQQPGFRVFRQKP