Protein Info for A4249_RS06405 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: NADH-quinone oxidoreductase subunit D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01962: NADH dehydrogenase (quinone), D subunit
  • amino acids 5 to 392 (388 residues), 587.5 bits, E=5.6e-181
• PF00346: Complex1_49kDa
  • amino acids 119 to 392 (274 residues), 405 bits, E=6.5e-126

Best Hits

Swiss-Prot: 80% identical to NUOD_CAUSK: NADH-quinone oxidoreductase subunit D (nuoD) from Caulobacter sp. (strain K31)

KEGG orthology group: K00333, NADH dehydrogenase I subunit D [EC: 1.6.5.3] (inferred from 94% identity to bsb:Bresu_1937)

MetaCyc: 63% identical to NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (Homo sapiens)
NADH-DEHYDROG-A-RXN [EC: 7.1.1.2]

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain D (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3 or 7.1.1.2

Sequence Analysis Tools

See A0A160I107 at UniProt or InterPro

Protein Sequence (392 amino acids)

>A4249_RS06405 NADH-quinone oxidoreductase subunit D (Brevundimonas sp. GW460-12-10-14-LB2)
MEDRKFTINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLMEARTYLQNVP
YLDRLDYVSPMNQEHAFCLAIEKLLGIEVPYRAQLIRVLYSEIGRILSHMLNVTTQAMDV
GALTPPLWGFEEREKLMVFYERACGARLHANYFRPGGVHQDLPMDLIDDIGRWCHEFPPA
LKDIESLVTENRIFKQRNVDIGVVSKQQALEWGFTGVMLRGSNIAWDLRKSQPYECYAEL
DFDVVVGKNGDCWDRYLVRIEEMKQSVRIMEQCIHKLRNCPGEPVMVEDNKIVPPRRGEM
KRSMESLIHHFKLYTEGFKTPEGEVYASVEAPKGEFGIYLVSDGTNKPYRVKISAPGFRS
LQAMDWMNRGHQLADVSAILGSLDIVFGEVDR