Protein Info for A4249_RS06380 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: NADH-quinone oxidoreductase subunit NuoG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 681 TIGR01973: NADH dehydrogenase (quinone), G subunit" amino acids 5 to 590 (586 residues), 703.3 bits, see alignment E=1.7e-215 PF13510: Fer2_4" amino acids 5 to 77 (73 residues), 47.8 bits, see alignment E=3.1e-16 PF00111: Fer2" amino acids 7 to 60 (54 residues), 34.2 bits, see alignment 5e-12 PF10588: NADH-G_4Fe-4S_3" amino acids 84 to 123 (40 residues), 58.4 bits, see alignment 1e-19 PF00384: Molybdopterin" amino acids 272 to 592 (321 residues), 323 bits, see alignment E=6.1e-100 PF09326: NADH_dhqG_C" amino acids 629 to 667 (39 residues), 40.3 bits, see alignment 1e-13

Best Hits

KEGG orthology group: K00336, NADH dehydrogenase I subunit G [EC: 1.6.5.3] (inferred from 82% identity to bsb:Bresu_1944)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain G (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HWU6 at UniProt or InterPro

Protein Sequence (681 amino acids)

>A4249_RS06380 NADH-quinone oxidoreductase subunit NuoG (Brevundimonas sp. GW460-12-10-14-LB2)
MPIAKVNGVETEFEPGMTVLQVAERAGQEIPRFCYHERLSIAGNCRMCLVEVKPGPPKPQ
ASCALPAADGQEIFTDTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQSVGYGRD
GSRYSENKRAVEEKAMGPTIKTFMTRCIQCTRCVRFITEVAGVPDIGMISRGEDAEITTY
LEKSVASELSGNVNDLCPVGALTHRPWQYHYRPWELKKTETIDVMDALGSNIRADYRGSE
VMRVLPRVNEGINEEWLSDKSRYVVDGLTARRLDRPWIRENGKLRAASWNEALDVVAAKL
KAAPAERIGVIAGDLQDAESMKATLDLFRALGSNNTDCRQDGAAVGYGPREGWLFNSGLE
GIEKADAVLIVGANPRTEAPLLNARLRKAWLKGDMEIGLIGEQADLTFDYAYLGAGTQTL
AKLPKSALDFLTKAERPAIIVGSGALVGEGGPSVLNALGALAKKVGVVADGWNGFNVLHH
AASRVAGLDMGFVPADGGLTVSEMLKPDALDVLFLLGADEVDPTGSNAFRVYLGSHGDRG
AHGADVILPGAAYTEKAGLYVNTEGRVQMAERVVFPKGEAKEDWAIIRALSARVDKTLPY
DTLEQLRAKLMGDHPTFGRIDYLPAPATFDVAALGAKGDLGDRAFVSAVTDPYLSNPIAR
ASATMAELSALRTQPVAMAAE