Protein Info for A4249_RS06285 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1154 TIGR00594: DNA polymerase III, alpha subunit" amino acids 10 to 1026 (1017 residues), 1159.7 bits, see alignment E=0 PF02811: PHP" amino acids 12 to 182 (171 residues), 108 bits, see alignment E=1.7e-34 PF07733: DNA_pol3_alpha" amino acids 300 to 564 (265 residues), 337 bits, see alignment E=2.2e-104 PF17657: DNA_pol3_finger" amino acids 567 to 728 (162 residues), 205.4 bits, see alignment E=9.5e-65 PF14579: HHH_6" amino acids 803 to 895 (93 residues), 97.3 bits, see alignment E=1.2e-31 PF01336: tRNA_anti-codon" amino acids 992 to 1058 (67 residues), 37 bits, see alignment 6.8e-13

Best Hits

Swiss-Prot: 72% identical to DPO3A_CAUVC: DNA polymerase III subunit alpha (dnaE1) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 84% identity to bsb:Bresu_2505)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I2F9 at UniProt or InterPro

Protein Sequence (1154 amino acids)

>A4249_RS06285 DNA polymerase III subunit alpha (Brevundimonas sp. GW460-12-10-14-LB2)
MNEPVNSQGFVHLRVRSAYSLLEGAIKAAKVGKLAADSGMPAVGVADRANLFGALEFSQT
AKDAGVQPIVACALPVFGIGGQINARWAKVPTVVLLAQDTAGWLNLCALSSSAYLDAGEM
AEPGVAWEQVVARSEGLILLSGGPDGPVDPLFAQGKKAEGAAALAAMRAAFGDRFYVELQ
RHGLEDEKRAEPGLVEWAYANDVPLVATNDVYYAKAGQAKSHDALLCIADGAFTGQEDRR
RITGEHWFKPAAVMREQFADLPEACDNTIDIARRCAFLVNTHAPILPRFDTGAGRSEADE
LAHQAREGLKVRLTEVTPAVPEEEYWTRLEWEVGIIQQMGFPGYFLIVSDFIKWAKTHGI
PVGPGRGSGAGSLVAWSLTITDLDPLRFGLLFERFLNPERVSMPDFDIDFCQERREEVID
YVQDRYGKDRVAQIITFGTLQARAVLRDVGRVLQMPLGQVDRLCKMVPNNPAAPVTLAQA
IDIEPRLKEARDAEPAVKTLLETALELEGLYRNASTHAAGIVIGDRPLTELVPLYQDPRS
TIPASQFNMKWVEPAGLVKFDFLGLKTLTVLDRARGYLERRGAAKDWNSLPLDDARTYEL
MASGQTVGVFQLESQGMRDTLRKMRCGSIEEITALISLYRPGPMEMIDTYIDRKFGRAEV
DYLHPSLKEVLTETYGVIIYQEQVMKIAQVLAGYSLGEADLLRRAMGKKKKEEMDFQRLR
FVKGAAEKAVPEAQSGSIFDLVAKFAGYGFNKSHAAAYALISFQTGWLKANQPVEFFAAS
MSLDLSNTDKLAVFYQDAKRFDVPVLAPDINRSSADFDVAWDDDKGAVLYALGAIRNVGL
EAMKHVIEVRETGGRFADIFDFLERVDPRSVNKRALEGLAKAGAFDSIHTNRRQLLEQAD
VLMAYCQSVAAERASSQVSLFGGDQAHAARPRLKSVEPWVGPERLDHELSAVGFYLSGHP
LDEMTSALKRKRVTFVAEAIPLAESGHEAFQMAGVVRRKQERASARTGEKFAFVTFSDPT
GEFECLFPPEQLRKCREVLEPGASVMVRVRAKSSEGEVRFFGDDASQMDNLLDDANIGLR
IHVSARSADAEALKARLERARSGAIGKGGEVSLMIAGLDQGREVEVKIPGRYRLDGALRG
ALKSAPGVVMLEDA