Protein Info for A4249_RS06250 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: phosphatidate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 272 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 34 to 51 (18 residues), see Phobius details amino acids 63 to 96 (34 residues), see Phobius details amino acids 108 to 125 (18 residues), see Phobius details amino acids 132 to 154 (23 residues), see Phobius details amino acids 173 to 194 (22 residues), see Phobius details amino acids 200 to 221 (22 residues), see Phobius details amino acids 250 to 268 (19 residues), see Phobius details PF01148: CTP_transf_1" amino acids 11 to 260 (250 residues), 186.6 bits, see alignment E=8.4e-59 PF01864: CarS-like" amino acids 171 to 260 (90 residues), 27.9 bits, see alignment E=2.2e-10

Best Hits

KEGG orthology group: K00981, phosphatidate cytidylyltransferase [EC: 2.7.7.41] (inferred from 68% identity to bsb:Bresu_2494)

Predicted SEED Role

"Phosphatidate cytidylyltransferase (EC 2.7.7.41)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.7.41)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168NGU5 at UniProt or InterPro

Protein Sequence (272 amino acids)

>A4249_RS06250 phosphatidate cytidylyltransferase (Brevundimonas sp. GW460-12-10-14-LB2)
MAVKGRDIALRAASAVVLAPAAVAATWGGGVWFLTLMIVASVVLAFEWAAMSAPHARRVM
GGAVSFGVVTAVISAHFGAMSVAFIMLVFGAVAAGVYARSRGQEALDAAYGVLYLGWPSV
LLIWLRDVDSLIGLHWTVLVFAVAWSADIVAYLAGSTFGGPKLWPRFSPNKTWSGFIGGV
AAGAVAGAVMTAWVNMGALSVVWGAVLGFAAALATMAGDLWESALKRRFGVKDAGNTIPG
HGGLLDRVDGLMFAVVVVAAGRLIVLMLERGA