Protein Info for A4249_RS05585 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: cystathionine beta-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 392 PF01053: Cys_Met_Meta_PP" amino acids 8 to 382 (375 residues), 319.1 bits, see alignment E=3e-99 TIGR01324: cystathionine beta-lyase" amino acids 8 to 384 (377 residues), 403.3 bits, see alignment E=4.1e-125 PF00155: Aminotran_1_2" amino acids 42 to 188 (147 residues), 32.1 bits, see alignment E=7.5e-12

Best Hits

KEGG orthology group: K01760, cystathionine beta-lyase [EC: 4.4.1.8] (inferred from 66% identity to bsb:Bresu_1917)

Predicted SEED Role

"Cystathionine beta-lyase (EC 4.4.1.8)" in subsystem Methionine Biosynthesis (EC 4.4.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.4.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HXQ9 at UniProt or InterPro

Protein Sequence (392 amino acids)

>A4249_RS05585 cystathionine beta-lyase (Brevundimonas sp. GW460-12-10-14-LB2)
MSPHSDRTRLIAAATRRGQGRRGVNPPIERASTMLSDSAAVMRDETDGPTYGLSGTSAAR
DLRRALADLEGAEGAFLVPSGLAAVTVPLLALLRPGDEVVTTDAVYGPTRRFLSRYQSTR
GVTTRFLPADADAQAVLAAIGERTRLVLMESPASLTFEMVDVTAVAQACRARGVLTVVDN
TWAAGLAYRPLAHCVDVSVQAVTKYVGGHSDVLMGSIASNDPACLRAIGDTIEDLGWHVS
PDDAWLALRGLRTLPLRYAEQARSALIVAEWLHGRPEVSRVLYPPLTNSISHDLWRRDFT
GAASLMGLIMKGGDKAAGEALLNALTLFGLGYSWGGFESLITHETHQMDYRCHPPVLEGE
LIRLHVGLEDPSELIADLERGLAAFTAALTVP