Protein Info for A4249_RS05435 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: RNA methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 265 PF08032: SpoU_sub_bind" amino acids 33 to 105 (73 residues), 27 bits, see alignment E=4.7e-10 PF00588: SpoU_methylase" amino acids 122 to 259 (138 residues), 119.4 bits, see alignment E=1.4e-38

Best Hits

KEGG orthology group: K03437, RNA methyltransferase, TrmH family (inferred from 83% identity to bsb:Bresu_2523)

Predicted SEED Role

"macromolecule metabolism; macromolecule synthesis, modification; rna synthesis, modification , dna transcription"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HXN3 at UniProt or InterPro

Protein Sequence (265 amino acids)

>A4249_RS05435 RNA methyltransferase (Brevundimonas sp. GW460-12-10-14-LB2)
MTERVITSLTNDTVKGVRALHMRKERDLTGTFLAEGLKFIGEALDQGRAPRMLLVGEDAR
PHSLLDRAKAATLKAGGDIIVVTHAILEKISRRDNPQTVLGVFEQAYAPLDSLNPASAPC
WVALEQVRDPGNLGTIIRTADAAGCGGVILIGDCVDPYSVEAVRATMGSVFAVSITKTTP
EAFLAWRKTWPGSVVGTRLDAKVSHRSAVMQQPSLILMGNEQAGLTDDLAAACDVNVKIP
MRGRADSLNLAIATGIMVYAATDEA