Protein Info for A4249_RS04785 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: YihY/virulence factor BrkB family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 314 transmembrane" amino acids 32 to 58 (27 residues), see Phobius details amino acids 105 to 123 (19 residues), see Phobius details amino acids 143 to 171 (29 residues), see Phobius details amino acids 191 to 209 (19 residues), see Phobius details amino acids 216 to 243 (28 residues), see Phobius details amino acids 250 to 276 (27 residues), see Phobius details PF03631: Virul_fac_BrkB" amino acids 30 to 284 (255 residues), 134.4 bits, see alignment E=3e-43

Best Hits

KEGG orthology group: K07058, membrane protein (inferred from 78% identity to bsb:Bresu_1776)

Predicted SEED Role

"Inner membrane protein YihY, formerly thought to be RNase BN"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I2H2 at UniProt or InterPro

Protein Sequence (314 amino acids)

>A4249_RS04785 YihY/virulence factor BrkB family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MSEQLTRSVLKAPGFWGGLAVRAFTRSWGRDVMLYTGGVSFFALLAVFPAIAILIGFYKL
GLSISEVSAQATALSDLLPKAAQTIFQGEITRLSNASARTVSAQSAFALFVGAYAAHRGF
KALLAGLNLIHDETEPHGFFKFNLLAFFVAIFAFALFTVVSGAVVTVRIMAHASSSAAGL
PGRSGMAPLDAFLPAIGLVIGLTLLYRYAMSHRAPVAWLPATAGGLVATLMSVVSSWLCA
IYVEQIAPLGATYGSVGAVVVLLIWLSWNVNAIFYGGAFATEMELAAKARTVADTPPADV
VNLSERRAGRRFRS