Protein Info for A4249_RS04780 in Brevundimonas sp. GW460-12-10-14-LB2
Annotation: diguanylate cyclase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K13591, two-component system, cell cycle response regulator PopA (inferred from 56% identity to cak:Caul_2708)Predicted SEED Role
"Pole remodelling regulatory diguanylate cyclase" in subsystem ZZ gjo need homes
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A168NX22 at UniProt or InterPro
Protein Sequence (435 amino acids)
>A4249_RS04780 diguanylate cyclase (Brevundimonas sp. GW460-12-10-14-LB2) MAFDARVLILAADDGRIGPLAAGLDALGWTTVTARDVISAEMTLQDFPLEAAVIDINTFD ADVASRLRAAAEPRRLPIVVIGARPDSVKGADLTMSTPPHPAQAALRLEQLGRAAIAEEE YRLRVTTFATRGVGLDKRTDDDGPLRVLAAGVADRRFLALSNALTAAGVEVVAAPTPYTA FDYLHESPFDAAVLWGAEDHAPALSIAAGMKRNTRLYHIPLMLYLRGRNEISLAELFNRG FADVASADTPEGETAERILALAGAHRIHLGIRKTLDSVRSLDVMDPETGLFTPELFASHL GRVAEASRARKRPLSVCVLRVRETESVTWARQGGWLDRAMPQIGAMVSRLVRVEDTPARL AKEVFALALPATHAEPARLAAERIAAVIGCTAFDAGPDRSPFVAEFDVGAAEMRPDESAA ALLERASADLFEKTR