Protein Info for A4249_RS04710 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: penicillin-binding protein 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 676 transmembrane" amino acids 23 to 41 (19 residues), see Phobius details TIGR03423: penicillin-binding protein 2" amino acids 21 to 613 (593 residues), 656.2 bits, see alignment E=2.5e-201 PF03717: PBP_dimer" amino acids 66 to 243 (178 residues), 152 bits, see alignment E=2.5e-48 PF00905: Transpeptidase" amino acids 278 to 609 (332 residues), 198.8 bits, see alignment E=1.2e-62

Best Hits

KEGG orthology group: K05515, penicillin-binding protein 2 (inferred from 77% identity to bsb:Bresu_2296)

Predicted SEED Role

"Penicillin-binding protein 2 (PBP-2)" in subsystem Peptidoglycan Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HXC0 at UniProt or InterPro

Protein Sequence (676 amino acids)

>A4249_RS04710 penicillin-binding protein 2 (Brevundimonas sp. GW460-12-10-14-LB2)
MSGEPSIFFADVNERQGSFLRRTFVLGGATALGITALIGRLGQLQVVQAQEYATLSSQNQ
FNFRMVPPPRGLIKDRNGVVIAGNRPSFRVLVVRDETKDLDQTLDLLGRLLPDTLERRRA
IIRDVNAASKFNPVPVKSDLTWEEFAKVNQYANELPGVMVDMNEARYYPFGGSFAHVIGY
VAKVSDRDVKAIRDKGEQPPALLFNPSFRIGRQGVEKALDTSLRGEPGGNRVEVDARGRV
VAEDIGGSRPAVPGKEVILTLDADVQNRALEVFGDESGACVVMDVRNGDILCMVSAPSFD
PNLFVGGVPTKTYRALADYERKPLLDKTLNGTFPPGSTFKPTTALALLEAGVDPKLTVFC
SGSYRTGNRTQRCWGRHGTQNMHDAIKNSCDVYFYAMCNRAGVDNIRKAGLALGFEHEFD
IGVGNQRKGLLPSTEWKARTFPRDPVWHPGETTSVAIGQGAITVNALQLAVMTSRLANGK
KQLQPRLIKSIGGVEQPSGAEAPDLPFDPAHVEYVRQGMIAVANDRSGTAYRQSQLGLGD
IQMAGKTGTAQVRNYGSGSRKSNIWALKDHNLFVAFAPVDAPRYAVAIIVEHGGKGGATA
GAPRAREVMRTVLLKDPDMRARIERPLPPEPTGDAIVEDGVVGAAPEPDVVAPPQPSRPA
PSATSGPRPYLSEPGR