Protein Info for A4249_RS04540 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: alkyl hydroperoxide reductase subunit C

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 187 TIGR03137: peroxiredoxin" amino acids 1 to 187 (187 residues), 331 bits, see alignment E=9.9e-104 PF00578: AhpC-TSA" amino acids 8 to 133 (126 residues), 118 bits, see alignment E=3.8e-38 PF08534: Redoxin" amino acids 11 to 140 (130 residues), 42 bits, see alignment E=1.3e-14 PF10417: 1-cysPrx_C" amino acids 155 to 182 (28 residues), 27.1 bits, see alignment 4.6e-10

Best Hits

Swiss-Prot: 72% identical to AHPC_SALTI: Alkyl hydroperoxide reductase C (ahpC) from Salmonella typhi

KEGG orthology group: K03386, peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC: 1.11.1.15] (inferred from 87% identity to cse:Cseg_0573)

MetaCyc: 71% identical to alkyl hydroperoxide reductase, AhpC component (Escherichia coli K-12 substr. MG1655)
R4-RXN [EC: 1.11.1.26]

Predicted SEED Role

"Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)" in subsystem Thioredoxin-disulfide reductase (EC 1.6.4.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15, 1.6.4.-

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.26 or 1.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HYL9 at UniProt or InterPro

Protein Sequence (187 amino acids)

>A4249_RS04540 alkyl hydroperoxide reductase subunit C (Brevundimonas sp. GW460-12-10-14-LB2)
MALINTTIKPFTAEAYKGGKFLTVTDADVAGKWAIFFFYPADFTFVCPTELEDLADHYAE
FQKLGVEIYSVSTDTHFSHKAWHDSSPAIGKIEYTMLGDPSGLVTNNFDAMRPGVGLADR
ATFLVDPDGVIQFTETTSEGIGRNAAELLRKVKAAQYVRSHPGEVCPAKWEEGEATLAPS
LDLVGKI