Protein Info for A4249_RS03735 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: amidophosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01134: amidophosphoribosyltransferase
  • amino acids 27 to 474 (448 residues), 488.8 bits, E=1e-150
• PF13522: GATase_6
  • amino acids 92 to 222 (131 residues), 72.5 bits, E=5.1e-24
• PF13537: GATase_7
  • amino acids 111 to 226 (116 residues), 76 bits, E=3.9e-25
• PF00156: Pribosyltran
  • amino acids 297 to 399 (103 residues), 33 bits, E=5.5e-12

Best Hits

Swiss-Prot: 59% identical to PUR1_RHIEC: Amidophosphoribosyltransferase (purF) from Rhizobium etli (strain CFN 42 / ATCC 51251)

KEGG orthology group: K00764, amidophosphoribosyltransferase [EC: 2.4.2.14] (inferred from 85% identity to bsb:Bresu_2358)

Predicted SEED Role

"Amidophosphoribosyltransferase (EC 2.4.2.14)" in subsystem De Novo Purine Biosynthesis (EC 2.4.2.14)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)

KEGG Metabolic Maps

• Glutamate metabolism
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.14

Sequence Analysis Tools

See A0A160HYA7 at UniProt or InterPro

Protein Sequence (501 amino acids)

>A4249_RS03735 amidophosphoribosyltransferase (Brevundimonas sp. GW460-12-10-14-LB2)
MRHHIADPVVHREHWREPEDDQLRLECGVCGVWGADEDEGSSVVALGLHALQHRGQEACG
IASVKDERFYTERHQGLVGEAFGGADLMTRMPGRAAVGHTRYSTAGGSFLRNIQPMFADL
DQGGIAIAHNGNLTNFKFLHAQLVSEGAIFQSTSDSEVILHLIARSRKAKIVDRFTDALA
RIEGGYALVAQTRTKMIGARDPLGIRPLVLGQLGDGWVLASETCALDMMGATFVRDVEHG
EIVVIDDSGLRSLKPFPARAARPCLFEYVYFSRPDSVVNGRSVYEVRKEMGRGLARELGV
EADIVVPVPDSGVPAALGYAQESGIPYEMGIIRSHYLGRTFIQPSQGARQKGVRMKHSPN
KSALAGKRVVLIDDSIVRGTTSLKLVRAVRAAGATEVHLRSASPQILFPDFYGIDMPERA
QLLAANKTLEEMRDMLEVDSLGFLSIDGLYRAMGETGRNPAAPQFTDHYFTGDYPTRLLD
REIEEGGREFGAKQLSLLVSA