Protein Info for A4249_RS03105 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: helix-turn-helix domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 144 PF00376: MerR" amino acids 14 to 50 (37 residues), 50.2 bits, see alignment E=2.7e-17 PF13411: MerR_1" amino acids 14 to 79 (66 residues), 56.6 bits, see alignment E=3.5e-19 PF09278: MerR-DNA-bind" amino acids 56 to 118 (63 residues), 74.5 bits, see alignment E=1.2e-24

Best Hits

Swiss-Prot: 39% identical to ZNTR_ECOLI: HTH-type transcriptional regulator ZntR (zntR) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 68% identity to bsb:Bresu_1648)

Predicted SEED Role

"Transcriptional regulator, MerR family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HXH0 at UniProt or InterPro

Protein Sequence (144 amino acids)

>A4249_RS03105 helix-turn-helix domain-containing protein (Brevundimonas sp. GW460-12-10-14-LB2)
MTLPSPASSGLRPIGKLAAATGVKVPTIRFYEEIGLLPAAPRTASDRRMYDDAAERRLSF
IRHARQLGFDLDSIRSLLDLSDHPDRPCAEASILAERHLAEVTHKIARLRALQRELLRMT
AECAGGRVSACKVIEALHDPSAPV