Protein Info for A4249_RS03025 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: IMP dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01302: inosine-5'-monophosphate dehydrogenase
  • amino acids 6 to 453 (448 residues), 627.4 bits, E=7.3e-193
• PF00478: IMPDH
  • amino acids 6 to 471 (466 residues), 539.3 bits, E=5.5e-166
• PF00571: CBS
  • amino acids 91 to 139 (49 residues), 38.7 bits, 1.6e-13
  • amino acids 149 to 202 (54 residues), 36.3 bits, 8.4e-13

Best Hits

Swiss-Prot: 59% identical to IMDH_HAEIN: Inosine-5'-monophosphate dehydrogenase (guaB) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K00088, IMP dehydrogenase [EC: 1.1.1.205] (inferred from 87% identity to bsb:Bresu_1634)

MetaCyc: 59% identical to inosine 5'-monophosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
IMP dehydrogenase. [EC: 1.1.1.205]

Predicted SEED Role

"Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) / CBS domain" in subsystem Purine conversions (EC 1.1.1.205)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• superpathway of purine nucleotide salvage (10/14 steps found)
• adenosine nucleotides degradation I (5/8 steps found)
• inosine 5'-phosphate degradation (2/4 steps found)
• purine nucleotides degradation I (plants) (7/12 steps found)
• ureide biosynthesis (3/7 steps found)
• purine nucleotides degradation II (aerobic) (5/11 steps found)
• superpathway of purines degradation in plants (8/18 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.205

Use Curated BLAST to search for 1.1.1.205

Sequence Analysis Tools

See A0A168NCX8 at UniProt or InterPro

Protein Sequence (485 amino acids)

>A4249_RS03025 IMP dehydrogenase (Brevundimonas sp. GW460-12-10-14-LB2)
MEIREGLTFDDVLLEPGASEFMPAMVDVSTQLTRDIKLNIPLLSSAMDTVTESRLAIAMA
QSGGLGVLHRNMTIEEQADEVRAVKRYESGMVVNPVTVGPQTTLGEVREIVARKKITGFP
VVDPATGKLVGMLTHRDMRFESDLNVTAASLMTTGDLITVREGASRDEARELLKTRKIER
VIVVDEDYRAVGLITMKDIEKAQAFPNAAKDEQGRLLVGAASTVGDAGYERAMALAEAGC
DVVVIDTAHGHSASVAQVVERIKRENNRLQIIAGNVATYDATRALIDAGADAVKVGIGPG
SICTTRIVAGVGVPQLTAVMDSARAAKGTGASVIADGGIKYSGDLAKAIAAGANVAMMGS
MFAGTDESPGEVFLYQGRSYKSYRGMGSVGAMARGSADRYFQKEVSSEKLVPEGIEGQTP
YKGPISPVLHQMVGGLRASMGYVGAGTIPEFQERARFVRITGAGLRESHVHDVMITREAP
NYRQG