Protein Info for A4249_RS03010 in Brevundimonas sp. GW460-12-10-14-LB2
Annotation: peptidylprolyl isomerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 37% identical to PPIL3_DICDI: Peptidyl-prolyl cis-trans isomerase-like 3 (ppil3) from Dictyostelium discoideum
KEGG orthology group: K01802, peptidylprolyl isomerase [EC: 5.2.1.8] (inferred from 85% identity to bsb:Bresu_1631)MetaCyc: 57% identical to glucuronan lyase (Sinorhizobium meliloti Rm2011)
Glucuronan lyase. [EC: 4.2.2.14]
Predicted SEED Role
"Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.2.1.8)
Isozymes
Compare fitness of predicted isozymes for: 5.2.1.8
Use Curated BLAST to search for 4.2.2.14 or 5.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A160HVK3 at UniProt or InterPro
Protein Sequence (153 amino acids)
>A4249_RS03010 peptidylprolyl isomerase (Brevundimonas sp. GW460-12-10-14-LB2) MADTLTFTLDTGDGEARDVVIKLRPDLAPGHVERITELAKEGFYDGVVFHRVIPGFMAQG GDPTGTGTSGSKKPNLKAEFSAEPHVRGVCSMARTSDPNSANSQFFIVFDDATFLDRQYT VWGQVESGMEHVDALPKGEPPRSPGKIVKATVN