Protein Info for A4249_RS02885 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: CaiB/BaiF CoA-transferase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: None (inferred from 58% identity to bsb:Bresu_1677)

MetaCyc: 49% identical to alpha-methylacyl-CoA racemase (Mycobacterium tuberculosis H37Rv)
Alpha-methylacyl-CoA racemase. [EC: 5.1.99.4]; 5.1.99.4 [EC: 5.1.99.4]; 5.1.99.4 [EC: 5.1.99.4]; 5.1.99.4 [EC: 5.1.99.4]

Predicted SEED Role

"Alpha-methylacyl-CoA racemase (EC 5.1.99.4)" (EC 5.1.99.4)

MetaCyc Pathways

cholesterol degradation to androstenedione II (cholesterol dehydrogenase) (3/22 steps found)
cholesterol degradation to androstenedione III (anaerobic) (1/22 steps found)
bile acid biosynthesis, neutral pathway (2/29 steps found)
superpathway of cholesterol degradation II (cholesterol dehydrogenase) (9/47 steps found)
superpathway of cholesterol degradation III (oxidase) (5/49 steps found)

KEGG Metabolic Maps

Bile acid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.99.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168NCE4 at UniProt or InterPro

Protein Sequence (360 amino acids)

>A4249_RS02885 CaiB/BaiF CoA-transferase family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MKPLNGVRIIEFDGLGPVTFAGMMLADLGAEVVRLTRDASAGPSVFDEVGGEVLHRGRAA
VPVDLKSPADRERILQLIDGADAVIEGFRPGVMERLGYGPDVVQARKPALVFGRVTGWGQ
TGPLANGVGHDLNYIGLSGVLHAMGEADRPPSPPLNLVGDYGGGAMLLVVGVLAALVEAR
TTGQGRVVDAAMTDGAALLGGLFQALRGRGLWSDQRGANLLDGGAPFYRCYACRDGGFVA
VAALEPRFYAALLAGLEIDPADAVQYDIAAWPALQARFAALFASRDRDDWSAHFAGTEAC
VTPVLGLAEAPAHPHNQARGTFHSGLPQPAPRFDGVVAAPSPKSELTLDQMVTKWSDHAG