Protein Info for A4249_RS02195 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: SDR family NAD(P)-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 325 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF08659: KR" amino acids 6 to 130 (125 residues), 23.3 bits, see alignment E=2.2e-08 PF01370: Epimerase" amino acids 6 to 252 (247 residues), 192.5 bits, see alignment E=3.2e-60 PF02719: Polysacc_synt_2" amino acids 6 to 130 (125 residues), 38 bits, see alignment E=4.5e-13 PF00106: adh_short" amino acids 6 to 92 (87 residues), 26.4 bits, see alignment E=1.8e-09 PF04321: RmlD_sub_bind" amino acids 6 to 249 (244 residues), 48.9 bits, see alignment E=2e-16 PF16363: GDP_Man_Dehyd" amino acids 7 to 313 (307 residues), 172.4 bits, see alignment E=7.3e-54 PF01073: 3Beta_HSD" amino acids 7 to 277 (271 residues), 65.6 bits, see alignment E=1.6e-21 PF07993: NAD_binding_4" amino acids 8 to 178 (171 residues), 23.1 bits, see alignment E=1.5e-08

Best Hits

Swiss-Prot: 49% identical to Y1055_METJA: Uncharacterized protein MJ1055 (MJ1055) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 77% identity to ccs:CCNA_02463)

Predicted SEED Role

"UDP-glucuronate 5'-epimerase (EC 5.1.3.12)" (EC 5.1.3.12)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168N8P9 at UniProt or InterPro

Protein Sequence (325 amino acids)

>A4249_RS02195 SDR family NAD(P)-dependent oxidoreductase (Brevundimonas sp. GW460-12-10-14-LB2)
MMGSPILVTGAAGFIGMHVAERLLDRGEQVIGVDVFNDYYDPRLKAARAARLEGRDNFRM
VRADIADHAQMLALVADAGVKRIVHLAAQAGVRYSLENPFAYERSNLAGHLSMLEAARHS
DVTHLVYASSSSVYGDRPLEGSGFREDDPTVHPVSLYAATKRSCELMSQSYAKLYGFPQS
GLRFFTVYGPWGRPDMAYFSFTQKIVRGEPIEVFGEGKMARDFTYIDDIVDGVIAVLDRP
PARGVHEIYNIGDSQPVGLMEMISTLETALGVEAKKIMRPMQPGDVTATYADISKLNALC
GYQPKAPLKIGLEKFVAWWRQYENG