Protein Info for A4249_RS02075 in Brevundimonas sp. GW460-12-10-14-LB2
Annotation: SMP-30/gluconolactonase/LRE family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 75% identity to bsb:Bresu_2946)MetaCyc: 46% identical to xylono-1,5-lactonase (Caulobacter vibrioides CB15)
RXN-12246 [EC: 3.1.1.110]
Predicted SEED Role
"Xylonolactonase (EC 3.1.1.68)" in subsystem Xylose utilization (EC 3.1.1.68)
MetaCyc Pathways
- D-xylose degradation V (5/5 steps found)
- D-xylose degradation III (4/5 steps found)
- D-xylose degradation VI (3/5 steps found)
- D-xylose degradation IV (4/7 steps found)
- superpathway of pentose and pentitol degradation (11/42 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 3.1.1.110 or 3.1.1.68
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A168N808 at UniProt or InterPro
Protein Sequence (284 amino acids)
>A4249_RS02075 SMP-30/gluconolactonase/LRE family protein (Brevundimonas sp. GW460-12-10-14-LB2) MSEPELIWHIQAELGEGPVWDAARAALWFVDIKGRKLHRYTPATGEKRSWDTPDQTGFAL PAEDGSLICGVRGGLYRFDPEEGDFSRFQPVEEDRPQNRLNDGFVAPDGSLWFGSMDDSE EVETGALYRWFRGELTRHDDGYGVTNGPCLSPDGRTLYHHDTLKKTVMAFDHYDGVISNK RVFAVTEDGYADGPSMDAAGVLHVGLFNGWGVARYAPDGARIGKIDMPVQTVTKAAFGGP DLRDLYMTTAWLGNADKRAEQPTLGGLYRTRVETPGLPQNLIRL