Protein Info for A4249_RS02020 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: sialate O-acetylesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 653 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF02837: Glyco_hydro_2_N" amino acids 291 to 369 (79 residues), 28.4 bits, see alignment E=1.5e-10 PF03629: SASA" amino acids 425 to 544 (120 residues), 31.1 bits, see alignment E=1.9e-11

Best Hits

KEGG orthology group: K05970, sialate O-acetylesterase [EC: 3.1.1.53] (inferred from 53% identity to cak:Caul_1304)

Predicted SEED Role

"Sialic acid-specific 9-O-acetylesterase"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168N7P3 at UniProt or InterPro

Protein Sequence (653 amino acids)

>A4249_RS02020 sialate O-acetylesterase (Brevundimonas sp. GW460-12-10-14-LB2)
MRSFLLAAAAFAALTGASPTQAQVQPQAAATAPLFDAMFQDHAVLQRGRPIKVWGRAAPG
AAVSVSLGQAQIQATAGLDGVWRASLPTLTAGGPYVLTARSAGATQNVSDIMIGDVWLCS
GQSNMEFTVRQATNAESEIGAANDDKIRLFLVGRSSLPAPSATPRAVGQWRVTSPQSVRD
FSAACYFMGRDLRRAENVPVGLIAASWGGSIIEDWLSRDAVEKLGGHQQALNALDAYARD
PAQGDAIWRRVTQDWWRANDPGTKQGWHLARTNDADWAPIPAEGFWESTVPGLATFDGIV
WLRKEIELTAAQARQAATLELGPVDDADVTWINGQYVGGQQGWDTPRTYAVPAGTLKAGR
NLIAVGVLDTNGGGGAWGPAANKRLVLADGTAVSLSSGWRHRVAAPLGDLPNPPRTPWIG
GSGTTTLYNGMIAPLGAYGLKGLAWYQGESNIGDYVGYRRLLPALFADWRARFENPEMRM
LVVQLANFGPMAGQPTNSYWAALRESQRTVVNADPLAGLAVAIDIGDRYDIHPTNKLEVG
RRLALEARRLDGQAQPVSPQPITVTRDADGVHIRYAASAQLVAHGSNRPVGFELCGADSA
CRFVDATLSQNEVVLSSASASDLKVRFCWADSPVCNLYGPAGLPAAPFEAEIR