Protein Info for A4249_RS00415 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: NAD-dependent deacylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02146: SIR2
  • amino acids 11 to 188 (178 residues), 133.2 bits, E=5.2e-43

Best Hits

Swiss-Prot: 58% identical to NPD_PASMU: NAD-dependent protein deacylase (cobB) from Pasteurella multocida (strain Pm70)

KEGG orthology group: K12410, NAD-dependent deacetylase [EC: 3.5.1.-] (inferred from 67% identity to aex:Astex_1628)

Predicted SEED Role

"NAD-dependent protein deacetylase of SIR2 family" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Redox-dependent regulation of nucleus processes

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Caprolactam degradation
• Glutathione metabolism
• Lipopolysaccharide biosynthesis
• Lysine biosynthesis
• Nicotinate and nicotinamide metabolism
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.-

Use Curated BLAST to search for 3.5.1.-

Sequence Analysis Tools

See A0A168MXL8 at UniProt or InterPro

Protein Sequence (236 amino acids)

>A4249_RS00415 NAD-dependent deacylase (Brevundimonas sp. GW460-12-10-14-LB2)
MSHTNLVVLTGAGISAESGVPTFRASDGLWCGHRVEDVATPEGYAVDPALVQDFYNQRRR
QLADVRPNAAHRALADLAARWEGDFLLVTQNVDDLHDRAHEQTPPAAGFELIHMHGELLK
GRCTRSGVVMGWAGDMAADQASPHHPEGVMRPHIVWFGEMPLQMERIERALEACDLFVSI
GTSGAVYPAAGFVQAARYAGARTVEINLEPTSVARLFDEGVYGPATQAVPAFFDTL