Protein Info for A4249_RS00370 in Brevundimonas sp. GW460-12-10-14-LB2
Annotation: acyl-CoA dehydrogenase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to ACADL_PIG: Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL) from Sus scrofa
KEGG orthology group: K00249, acyl-CoA dehydrogenase [EC: 1.3.99.3] (inferred from 88% identity to bsb:Bresu_0831)MetaCyc: 48% identical to long-chain-acyl-CoA dehydrogenase monomer (Homo sapiens)
LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.8]; 1.3.8.8 [EC: 1.3.8.8]; RXN-21775 [EC: 1.3.8.8, 1.3.8.7]
Predicted SEED Role
"Butyryl-CoA dehydrogenase (EC 1.3.8.1)" (EC 1.3.8.1)
MetaCyc Pathways
- oleate β-oxidation (27/35 steps found)
- 2-methyl-branched fatty acid β-oxidation (11/14 steps found)
- fatty acid salvage (5/6 steps found)
- adipate degradation (4/5 steps found)
- superpathway of coenzyme A biosynthesis II (plants) (7/10 steps found)
- valproate β-oxidation (6/9 steps found)
- β-alanine biosynthesis II (3/6 steps found)
- (8E,10E)-dodeca-8,10-dienol biosynthesis (5/11 steps found)
KEGG Metabolic Maps
- Fatty acid metabolism
- Propanoate metabolism
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.3.8.7
Use Curated BLAST to search for 1.3.8.1 or 1.3.8.7 or 1.3.8.8 or 1.3.99.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A168MXD2 at UniProt or InterPro
Protein Sequence (387 amino acids)
>A4249_RS00370 acyl-CoA dehydrogenase family protein (Brevundimonas sp. GW460-12-10-14-LB2) MNVLGSPDPDFMREEEITLFSDSVGKWIDEHAPLEKVQQWIADSSVPRQLWNDAGEAGLL GLSLPEEDGGFGGDYRHEVVLMRQLGWKGADHFGISLHNAIVMPYIWHYGTEEQKARWLP RLQSGELVGAIAMTEPGAGSDLQGVKTTAIKSGNGYVVNGSKTFITNGQLANFLIVVAKT DPAEGAKGTSLIVVETDGAEGFERGRNLHKIGMEANDTSELFFNDVKVPGDNIIGGTEGQ GFVQLMQQLPQERLNIAVQGVAAAERGLEATLAYVKERKAFGKRVIDFQNTQFKLAEVKT KLTVAKVFTDHCIGLHLQGKLDAATASMAKYWVTDIQGETIDEMLQLHGGYGYMNEYPIA QLYKDARVQRIYGGTNEIMKLLIARTL