Protein Info for A4249_RS00135 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: cytochrome c oxidase subunit 3

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00510: COX3
  • amino acids 10 to 299 (290 residues), 265.5 bits, E=3.3e-83

Best Hits

KEGG orthology group: K02276, cytochrome c oxidase subunit III [EC: 1.9.3.1] (inferred from 79% identity to bsb:Bresu_0806)

Predicted SEED Role

"Cytochrome c oxidase polypeptide III (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

• aerobic respiration I (cytochrome c) (3/4 steps found)
• aerobic respiration II (cytochrome c) (yeast) (3/4 steps found)
• arsenite to oxygen electron transfer (1/2 steps found)
• arsenite to oxygen electron transfer (via azurin) (1/3 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

See A0A168MW64 at UniProt or InterPro

Protein Sequence (302 amino acids)

>A4249_RS00135 cytochrome c oxidase subunit 3 (Brevundimonas sp. GW460-12-10-14-LB2)
MADAHATPQHDYHLVAPSPWPLVSSVAATIMFIGAVIWMKGLAPADGGPIAANFLAEGKP
GVFFAGLAGVLISAFCWWADVIKESKAGDHTPVVSLGLRYGMILFIASEVMFFVAFFWMF
FDMALFHESRALTPEVGTWADTAKAWSTWPPKGVEVLSPWQLPLLNTVTLLLSGCTVTWA
HHAIQVGDRKGAKLALIITVALGVLFTCVQAYEYNHILHEKLFFNEEAVNSGLYGSIFFM
ATGFHGFHVLIGTIFLAVCLIRLLKGDFTPQKHFGFEAAAWYWHFVDVVWLFLFAFVYVV
FG