Protein Info for b3747 in Escherichia coli BW25113

Name: trkD
Annotation: potassium transporter (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 49 to 69 (21 residues), see Phobius details amino acids 101 to 125 (25 residues), see Phobius details amino acids 139 to 157 (19 residues), see Phobius details amino acids 168 to 190 (23 residues), see Phobius details amino acids 212 to 233 (22 residues), see Phobius details amino acids 245 to 265 (21 residues), see Phobius details amino acids 285 to 311 (27 residues), see Phobius details amino acids 337 to 357 (21 residues), see Phobius details amino acids 363 to 383 (21 residues), see Phobius details amino acids 395 to 413 (19 residues), see Phobius details amino acids 422 to 440 (19 residues), see Phobius details PF02705: K_trans" amino acids 14 to 544 (531 residues), 729.6 bits, see alignment E=1.1e-223 TIGR00794: potassium uptake protein" amino acids 97 to 550 (454 residues), 670.3 bits, see alignment E=1.8e-205

Best Hits

Swiss-Prot: 100% identical to KUP_ECO45: Low affinity potassium transport system protein kup (kup) from Escherichia coli O45:K1 (strain S88 / ExPEC)

KEGG orthology group: K03549, KUP system potassium uptake protein (inferred from 100% identity to ecg:E2348C_4057)

MetaCyc: 100% identical to K+:H+ symporter Kup (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-3

Predicted SEED Role

"Kup system potassium uptake protein" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P63183 at UniProt or InterPro

Protein Sequence (622 amino acids)

>b3747 potassium transporter (NCBI) (Escherichia coli BW25113)
MSTDNKQSLPAITLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLL
IFVVSIKYLTFVMRADNAGEGGILTLMSLAGRNTSARTTSMLVIMGLIGGSFFYGEVVIT
PAISVMSAIEGLEIVAPQLDTWIVPLSIIVLTLLFMIQKHGTAMVGKLFAPIMLTWFLIL
AGLGLRSIIANPEVLHALNPMWAVHFFLEYKTVSFIALGAVVLSITGVEALYADMGHFGK
FPIRLAWFTVVLPSLTLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLIIAALATVIA
SQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFVNWMLYVAVVIVIVSFEHS
SNLAAAYGIAVTGTMVLTSILSTTVARQNWHWNKYFVALILIAFLCVDIPLFTANLDKLL
SGGWLPLSLGTVMFIVMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVYM
SRAINVIPFALMHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSPTFWRVVASY
GWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLILGKRPWYLRLRGKLYLLLQRNAL
RAPDQFEIPPNRVIELGTQVEI