Protein Info for b3745 in Escherichia coli BW25113

Name: yieM
Annotation: predicted von Willibrand factor containing protein (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 483 PF05762: VWA_CoxE" amino acids 320 to 457 (138 residues), 41.1 bits, see alignment E=1.4e-14 PF13519: VWA_2" amino acids 323 to 422 (100 residues), 34.4 bits, see alignment E=3.1e-12

Best Hits

Swiss-Prot: 100% identical to VIAA_ECOLI: Protein ViaA (viaA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to eco:b3745)

Predicted SEED Role

"FIG00637882: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0ADN0 at UniProt or InterPro

Protein Sequence (483 amino acids)

>b3745 predicted von Willibrand factor containing protein (NCBI) (Escherichia coli BW25113)
MLTLDTLNVMLAVSEEGLIEEMIIALLASPQLAVFFEKFPRLKAAITDDVPRWREALRSR
LKDARVPPELTEEVMCYQQSQLLSTPQFIVQLPQILDLLHRLNSPWAEQARQLVDANSTI
TSALHTLFLQRWRLSLIVQATTLNQQLLEEEREQLLSEVQERMTLSGQLEPILADNNTAA
GRLWDMSAGQLKRGDYQLIVKYGEFLNEQPELKRLAEQLGRSREAKSIPRNDAQMETFRT
MVREPATVPEQVDGLQQSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGESW
REKVIERPVVHKDYDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRIALAENRRCYI
MLFSTEIVRYELSGPQGIEQAIRFLSQQFRGGTDLASCFRAIMERLQSREWFDADAVVIS
DFIAQRLPDDVTSKVKELQRVHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRR
WRR